eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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vol. 4
Original paper

Ombitasvir/paritaprevir/ritonavir + dasabuvir + ribavirin in HCV genotype 1 infected patients who failed previous protease inhibitor therapy

Béla Hunyady
Margit Abonyi
Zsuzsanna Gerlei
Judit Gervain
Gábor Horváth
Viktor Jancsik
Gabriella Lengyel
Erzsébet Makkai
Alajos Pár
Zoltán Péter
Margit Pusztay
Pál Ribiczey
László Rókusz
Christoph Sarrazin
Ferenc Schneider
Simone Susser
Ferenc Szalay
István Tornai
Anna Tusnádi
Eszter Újhelyi
Klára Werling
Mihály Makara

Clin Exp HEPATOL 2018; 4, 2: 83-90
Online publish date: 2018/05/25
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Aim of the study
Combination of ombitasvir/paritaprevir/ritonavir + dasabuvir ± ribavirin (3DDA±RBV) therapy is shown to be effective in HCV genotype 1 (GT1) infected patients. However, sparse data exist in patients who failed previous boceprevir or telaprevir based therapies. Real life efficacy and safety of this combination were evaluated in HCV GT1b infected patients (mostly cirrhotics) with compensated liver disease who failed previous boceprevir or telaprevir based therapies more than a year before.

Material and methods
Data of previous protease inhibitor failure patients, treated with 3DAA+RBV for 12 weeks (GT1b and/or non-cirrhotics) or 24 weeks (non-GT1b cirrhotics), were retrospectively collected.

Population characteristics: boceprevir/telaprevir-failure: 82/45, GT1b: 117, cirrhotic: 111 (87.4%). SVR12/24 was observed in 103/105 patients (98.1%) of those who reached either time point. Four SAEs reported: one death due to myocardial infarction, another due to recurrent hepatocellular carcinoma after achieving SVR12, two hospitalizations (elevation of transaminases, pneumonia). Grade ≥ 3 AEs or laboratory abnormalities were reported in < 10% of patients; they were transient in all patients. No early discontinuation of drugs due to SAE has been reported.

One year after previous failure of boceprevir or telaprevir based therapy, 12 weeks of 3DAA+RBV combination in HCV GT1b infected patients is similarly effective and safe as in those with no previous HCV therapy, even in the presence of cirrhosis. These findings might be of particular interest in settings where alternative therapies for such patients are not available or not affordable.


cirrhosis, direct acting antiviral drugs, hepatitis C virus, protease inhibitor

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