eISSN: 2084-9885
ISSN: 1896-6764
Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology
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vol. 8

Original article
Personality traits measured with TEMPS-A and O-LIFE and polymorphism of BDNF, COMT and serotonin transporter genes in bipolar affective illness

Janusz Rybakowski
Monika Dmitrzak-Węglarz
Daria Dembińska-Krajewska
Joanna Hauser

Neuropsychiatria i Neuropsychologia 2013; 8, 3–4: 94–100
Online publish date: 2014/01/30
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Aim of the study: This study assesses an association between functional polymorphisms of the brain-derived neurotrophic factor (BDNF) gene, catechol-O-methyltransferase (COMT) gene and serotonin transporter gene and personality dimensions measured by the Temperament Scale of Memphis, Pisa, Paris and San Diego – Autoquestionnaire (TEMPS-A) and the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE) in patients with bipolar affective illness.

Material and methods: The study was performed on 70 patients with bipolar affective illness (21 men, 49 women) aged 59 ±12 years, from the outpatient clinic, Department of Adult Psychiatry, Poznan University of Medical Sciences. The TEMPS-A was applied, measuring depressive, hyperthymic, cyclothymic, irritable and anxious temperament as well as the O-LIFE, measuring schizotypy dimensions: unusual experiences, cognitive disorganization, introversion and anhedonia and impulsive nonconformity. Genotyping of Val66Met polymorphism of the BDNF gene, Val108Met polymorphism of the COMT gene and 5-HTLPR s/l polymorphism of the serotonin transporter gene was performed.

Results: Carriers of the Met allele of Val66Met BDNF gene polymorphism showed significantly higher irritability dimension on TEMPS-A. Among carriers of the Met allele of Val108Met COMT gene polymorphism, significantly higher cognitive disorganization and introvertive anhedonia on O-LIFE were observed. Finally, patients with s/s genotype of 5-HTLPR polymorphism had a higher cyclothymia dimension at the level of a statistical trend (p = 0.06).

Conclusions: The association between BDNF gene polymorphism and irritability in the TEMPS-A has not been previously reported. A connection between the COMT gene and features of schizotypy as well as between the serotonin transporter gene and cyclothymia is discussed in the context of results of other researchers.

bipolar disorder, TEMPS-A, O-LIFE, BDNF, COMT, 5-HTT

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