eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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vol. 2

Original papers
Long-term follow-up of rapamycin-eluting stent implantation in patients with coronary artery disease

Jan Peruga
Jarosław D. Kasprzak
Anna Kopff
Michał Kidawa
Michał Plewka
Maria Krzemińska-Pakuła

Postępy w Kardiologii Interwencyjnej 2006; 2, 3 (5): 214–218
Online publish date: 2006/10/13
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Restenosis remains the major limitation of percutanoues coronary interventions (PCI). Widespread use of conventional intracoronary stents has lowered its frequency. However, repeat narrowing of a coronary artery can still affect 10% to 30% of patients post PCI.
Objective: The aim of the study was to assess the efficacy of rapamycin-eluting stent (DES) implantation in patients at highest risk of restenosis in case of conventional bare-metal stent implantation.
Results: Rapamycin-eluting stent implantation was performed in 286 patients, including 8 patients (2.8%) with acute myocardial infarction and 98 (34.2%) patients with unstable angina. Restenosis post previous PCI was the indication for DES implantation in 80.4% of patients. The procedure was successful in all patients. During the average 28.7-month follow-up 6 deaths occurred, including 4 (1.4%) probably coronary-related deaths, and in 8 patients acute myocardial infarction was diagnosed. In 59 (20.6%) patients control coronary angiography was performed 6-9 months after the procedure. In-stent restenosis was diagnosed in one (0.4%) patient and in 18 patients restenosis within 5 mm of either pole of DES was seen. No cases of stent thrombosis were revealed.
Conclusions: In patients with coronary artery disease at highest risk of restenosis in case of conventional bare-metal stent implantation, drug-eluting stents significantly reduce restenosis rate and the need for repeated PCI, thus improving the outcome of percutaneous treatment of coronary artery disease.

coronary angioplasty, drug eluting stents

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