Menopause Review
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eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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4/2022
vol. 21
 
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abstract:
Review paper

Oxidative homeostasis in follicular fluid and reproductive outcomes – from bench to bedside

Ivana Zec
1
,
Marina Šprem Goldštajn
2
,
Krunoslav Kuna
3
,
Mislav Mikuš
2
,
Guglielmo Stabile
4
,
Bianca Bianco
5, 6
,
Giovanni Buzzaccarini
7
,
Antonio Simone Laganà
8

  1. Laboratory of Endocrinology, Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia
  2. Department of Obstetrics and Gynaecology, Division of Reproductive Endocrinology and Reproductive Medicine, Zagreb University Hospital Centre, University of Zagreb, School of Medicine, Zagreb, Croatia
  3. Department of Gynaecology and Obstetrics, Sestre Milosrdnice University Hospital Centre, Zagreb, Croatia
  4. Department of Obstetrics and Gynaecology, Institute for Maternal and Child Health-IRCCS “Burlo Garofolo”, Trieste, Italy
  5. Discipline of Sexual and Reproductive Health, and Populational Genetics – Department of Collective Health, Faculdade de Medicina do ABC/Centro Universitário FMABC, Santo André, Brazil
  6. Department of Urology, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazi
  7. Department of Obstetrics and Gynaecology, IRRCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy
  8. Unit of Gynecologic Oncology, ARNAS "Civico – Di Cristina – Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy
Menopause Rev 2022; 21(4): 276-284
DOI: https://doi.org/10.5114/pm.2022.124019
Online publish date: 2022/12/30
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Free radicals and oxidant molecules are part of our organism in a stable balance. However, when addressing female infertility, questions about their role in oocyte quality arise. This review outlines the major alterations of redox homeostasis in the follicular fluid through pathophysiological conditions in female reproduction and its potential effect on IVF outcome. A review of the literature was accurately performed. Manuscripts investigating follicular fluid biomarkers, especially related to oxidant molecules, were screened and used in this review. Studies assessing the follicular reactive species were found and screened. Moreover, studies assessing the IVF outcomes related to biomarkers were considered. The results are provided in an analytical pathway. The study of biomarkers confirms the shift to enhanced oxidizing modification of macromolecules and antioxidative consumption in the follicular fluid of women undergoing IVF treatment. A lack of congruency in methods appears to be marked in the design of scientific studies. However, it is not clear whether redox disbalance has a disruptive effect on the oocyte competence or whether it plays a role in the oocyte maturation process. Red-ox balance plays a questionable role in IVF outcomes. Possible further insights may consider the antioxidant role of adjuvants during controlled ovarian stimulation cycles.
keywords:

reactive-oxygen species; follicular fluid; oxidant; in vitro fertilization; assisted reproductive techniques

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