Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances

Dominik Samotij; Bogusław Nedoszytko; Joanna Bartosińska; Aleksandra Batycka-Baran; Rafał Czajkowski; Iwona Dobrucki; Lawrence Dobrucki; Magdalena Górecka-Sokołowska; Anna Janaszak-Jasienicka; Dorota Krasowska; Leszek Kalinowski; Marta Macieja-Stawczyk; Roman Nowicki; Agnieszka Owczarczyk-Saczonek; Agata Płoska; Dorota Purzycka-Bohdan; Adrianna Radulska; Edyta Reszka; Anna Siekierzycka; Andrzej Słomiński; Radomir Słomiński; Marta Sobalska-Kwapis; Dominik Strapagiel; Aneta Szczerkowska-Dobosz; Justyna Szczęch; Michał Żmijewski; Adam Reich

doi:10.5114/ada.2020.94832

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances

Dominik Samotij

¹

,

Bogusław Nedoszytko

²

,

Joanna Bartosińska

³

,

Aleksandra Batycka-Baran

⁴

,

Rafał Czajkowski

⁵

,

Iwona T. Dobrucki

⁶

,

Lawrence W. Dobrucki

^{6, 7, 8, 9}

,

Magdalena Górecka-Sokołowska

¹⁰

,

Anna Janaszak-Jasienicka

^{8, 9}

,

Dorota Krasowska

³

,

Leszek Kalinowski

^{8, 9}

,

Marta Macieja-Stawczyk

²

,

Roman J. Nowicki

²

,

Agnieszka Owczarczyk-Saczonek

¹¹

,

Agata Płoska

^{8, 9}

,

Dorota Purzycka-Bohdan

²

,

Adrianna Radulska

^{8, 9}

,

Edyta Reszka

¹²

,

Anna Siekierzycka

^{8, 9}

,

Andrzej Słomiński

^{13, 14, 15}

,

Radomir Słomiński

¹⁶

,

Marta Sobalska-Kwapis

¹⁷

,

Dominik Strapagiel

¹⁷

,

Aneta Szczerkowska-Dobosz

²

,

Justyna Szczęch

¹

,

Michał Żmijewski

¹⁸

,

Adam Reich

¹

Department of Dermatology, University of Rzeszow, Rzeszow, Poland

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland

Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland

Department of Dermatology and Venereology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland

Beckman Institute for Advanced Science and Technology, Urbana, IL, USA

Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA

Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland

Biobanking and Biomolecular Resources Research Infrastructure, (BBMRI.PL), Gdansk, Poland

10.

Department of Dermatology, Sexually Transmitted Disorders and Immunodermatology, Jurasz University Hospital No. 1, Bydgoszcz, Poland

11.

Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland

12.

Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland

13.

Department of Dermatology, Birmingham, AL, USA

14.

Comprehensive Cancer Center, Cancer Chemoprevention Program, Birmingham, AL, USA

15.

VA Medical Center, Birmingham, AL, USA

16.

Department of Medicine, Division of Rheumatology, University of Alabama, Birmingham, AL, USA

17.

Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland

18.

Department of Histology, Medical University of Gdansk, Gdansk, Poland

Adv Dermatol Allergol 2020; XXXVII (2): 135–153

DOI: https://doi.org/10.5114/ada.2020.94832

Online publish date: 2020/05/05

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AMA

Samotij D, Nedoszytko B, Bartosińska J, et al. Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(2):135-153. doi:10.5114/ada.2020.94832.

APA

Samotij, D., Nedoszytko, B., Bartosińska, J., Batycka-Baran, A., Czajkowski, R.,  & Dobrucki, I. T. et al. (2020). Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(2), 135-153. https://doi.org/10.5114/ada.2020.94832

Chicago

Samotij, Dominik, Bogusław Nedoszytko, Joanna Bartosińska, Aleksandra Batycka-Baran, Rafał Czajkowski, Iwona T Dobrucki,  and Lawrence W Dobrucki et al. 2020. "Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 37 (2): 135-153. doi:10.5114/ada.2020.94832.

Harvard

Samotij, D., Nedoszytko, B., Bartosińska, J., Batycka-Baran, A., Czajkowski, R., Dobrucki, I., Dobrucki, L., Górecka-Sokołowska, M., Janaszak-Jasienicka, A., Krasowska, D., Kalinowski, L., Macieja-Stawczyk, M., Nowicki, R., Owczarczyk-Saczonek, A., Płoska, A., Purzycka-Bohdan, D., Radulska, A., Reszka, E., Siekierzycka, A., Słomiński, A., Słomiński, R., Sobalska-Kwapis, M., Strapagiel, D., Szczerkowska-Dobosz, A., Szczęch, J., Żmijewski, M.,  and Reich, A. (2020). Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(2), pp.135-153. https://doi.org/10.5114/ada.2020.94832

MLA

Samotij, Dominik et al. "Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 37, no. 2, 2020, pp. 135-153. doi:10.5114/ada.2020.94832.

Vancouver

Samotij D, Nedoszytko B, Bartosińska J, Batycka-Baran A, Czajkowski R, Dobrucki I et al. Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(2):135-153. doi:10.5114/ada.2020.94832.

Psoriasis is a common, chronic, inflammatory, immune-mediated skin disease affecting about 2% of the world’s population. According to current knowledge, psoriasis is a complex disease that involves various genes and environmental factors, such as stress, injuries, infections and certain medications. The chronic inflammation of psoriasis lesions develops upon epidermal infiltration, activation, and expansion of type 1 and type 17 Th cells. Despite the enormous progress in understanding the mechanisms that cause psoriasis, the target cells and antigens that drive pathogenic T cell responses in psoriatic lesions are still unproven and the autoimmune basis of psoriasis still remains hypothetical. However, since the identification of the Th17 cell subset, the IL-23/Th17 immune axis has been considered a key driver of psoriatic inflammation, which has led to the development of biologic agents that target crucial elements of this pathway. Here we present the current understanding of various aspects in psoriasis pathogenesis.

keywords:

Pathogenesis of psoriasis in the “omic” era. Part I. Epidemiology, clinical manifestation, immunological and neuroendocrine disturbances

psoriasis, interleukins, autoimmunity, neurogenic inflammation, neoangiogenesis