|
Current issue
Archive
Online First
About the journal
Editorial board
Abstracting and indexing
Subscription
Contact
Ethical standards and procedures
Special Issues
Instructions for authors
Publication charge
Editorial System
Submit your Manuscript
Open access 
|
1/2011
vol. 10 abstract:
Original paper
The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination (XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland
Hanna Romanowicz
,
Beata Smolarz
,
Jakub Baszczyński
,
Marek Zadrożny
,
Andrzej Kulig
,
Bożena Góralczyk
,
Ireneusz Połać
,
Tomasz Pertyński
Przegląd Menopauzalny 2011; 1: 10–14
Online publish date: 2011/03/16
View
full text
Get citation
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
Background : Single nucleotide polymorphisms in the DNA repair genes have been extensively studied in association with various human cancers such as breast cancer.
Material and methods : We investigated an association of polymorphisms in the DNA repair genes XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assays in 80 patients with breast cancer and 80 controls. Results : The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differ significantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51 increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91–5.72), p = 0.04). Conclusion : G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadic breast cancer in Polish women. keywords:
XRCC2, RAD51, breast cancer, gene polymorphism |
 |
