eISSN: 1731-2531
ISSN: 1642-5758
Anaesthesiology Intensive Therapy
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
vol. 55
Original article

Predictive role of selected biomarkers in differentiating gram-positive from gram-negative sepsis in surgical patients: a retrospective study

Nenad Nešković
1, 2
Domagoj Drenjančević
2, 3
Slavica Kvolik
1, 2
Sonja Škiljić
1, 2
Dino Budrovac
1, 2
Ivana Haršanji Drenjančević
1, 2

Department of Anaesthesiology, Resuscitation, and Intensive Care, Osijek University Hospital, Croatia
Faculty of Medicine, University Josip Juraj Strossmayer Osijek, Croatia
Department of Clinical Microbiology and Hospital Infections, Osijek University Hospital, Croatia
Anaesthesiol Intensive Ther 2023; 55, 4: 319–325
Online publish date: 2024/12/30
View full text Get citation
PlumX metrics:
Patients after major surgery are at high risk of developing sepsis, which is accompanied by elevated serum levels of C-reactive protein (CRP) and procalcitonin (PCT). This study aimed to examine the differences in serum biomarker levels concerning the causative agent of sepsis in surgical patients.

Material and methods:
A retrospective study was carried out in the surgical intensive care unit (ICU) and included 81 septic patients admitted from January 2019 to May 2022, who had positive blood cultures (BC). Serum levels of PCT, CRP, white blood cells (WBC) and platelet counts were recorded on the day of the positive BC and over the following 3 days.

Patients with gram(–) sepsis had significantly higher PCT levels, and lower platelet count compared to patients with gram(+) sepsis. High PCT and low platelets levels in all measurements were a significant predictor of gram(–) isolate with the highest predictive value on the third day after BC sampling, with AUROC 0.821 (95% CI: 0.692–0.950), P = 0.001, and AUROC 0.676 (95% CI: 0.541–0.811), P = 0.02, respectively. In multivariate logistic regression, platelets the day after BC sampling and PCT on the third day made a significant contribution in distinguishing gam(+) from gram(–) BC. Age and high serum CRP levels were significant predictors of poor outcomes.

PCT and platelets may be useful biomarkers for predicting the causative agent of sepsis in surgical patients.


blood culture, critical care, C-reactive protein, procalcitonin, sepsis, surgery

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.