eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
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vol. 17
Review paper

Premature ovarian insufficiency – aetiopathology, epidemiology, and diagnostic evaluation

Ewa Rudnicka
Jagoda Kruszewska
Klaudia Klicka
Joanna Kowalczyk
Monika Grymowicz
Jolanta Skórska
Wojciech Pięta
Roman Smolarczyk

Menopause Rev 2018; 17(3): 105-108
Online publish date: 2018/09/30
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Premature ovarian insufficiency (POI) is defined as a cessation of ovarian function before the age of 40 years. It is associated with hypoestrogenism and loss of residual follicles, both of which lead to menstrual abnormalities, pregnancy failures, and decreased health-related quality of life. The prevalence of POI is estimated at 1% in the general population. Current European Society of Human Reproduction and Embryology (ESHRE) diagnostic criteria include: amenorrhoea or oligomenorrhoea for at least four months and increased follicle-stimulating hormone (FSH) levels > 25 IU/l measured twice (with a four-week interval). The aetiopathogenesis of the disease in most cases remains unexplained. Nevertheless, in some patients with POI, genetic abnormalities, metabolic disorders, autoimmunity, iatrogenic procedures, infections, or environmental factors have been established as underlying causes of the syndrome.

premature ovarian insufficiency, Turner syndrome, autoimmunity

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