en ENGLISH
eISSN: 2300 - 8660
ISSN: 0031-3939
Pediatria Polska - Polish Journal of Paediatrics
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Rada naukowa Bazy indeksacyjne Kontakt Zasady publikacji prac Standardy etyczne i procedury
SCImago Journal & Country Rank

 
2/2021
vol. 96
 
Poleć ten artykuł:
Udostępnij:
więcej
 
 
streszczenie artykułu:
Artykuł oryginalny

Primary nasopharyngeal Burkitt’s lymphoma in paediatric patients in a non-endemic region: our experience

Santosh K. Swain
1
,
Ansuman Sahu
1
,
Smrutipragnya Samal
1

1.
Department of Otorhinolaryngology, IMS and SUM Hospital, Siksha “O” Anusandhan University, Kalinganagar, Bhubaneswar, Odisha, India
Pediatr Pol 2021; 96 (2): 109–114
Data publikacji online: 2021/07/01
Pełna treść artykułu
Pobierz cytowanie
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Metryki PlumX:


Introduction
Burkitt’s lymphoma (BL) is an aggressive type of B-cell non-Hodgkin’s lymphoma. BL is common in paediatric age in regions where malaria is holoendemic. Its incidence is also high in immunosuppressed patients in non-endemic regions, especially when associated with HIV infection. Primary BL at the nasopharynx in the paediatric age group is extremely rare, especially in non-endemic areas. It often results in misdiagnosis and delayed treatment. BL becomes fatal if untreated or treated late. The aim of this study is to evaluate the clinical presentations, investigations, and treatment of nasopharyngeal BL among paediatric patients in a non-endemic region.

Material and methods
This was a retrospective study in which 21 paediatric patients with nasopharyngeal BL were enrolled, with age under 18 years. This study was done between July 2010 and August 2020.

Results
There were 21 children with nasopharyngeal BL included in this study; 17 male and 4 female, with a male-to-female ratio of 4.25:1. The most common presenting symptoms were nasal block (100%), epistaxis (71.42%), rhinorrhoea (66.66%), snoring (57.14%), and headache (42.85%). The most common location of the nasopharynx was the roof of the nasopharynx (28.57%), lateral wall (23.805), posterior wall (19.04%), and junction of the roof and posterior wall (28.57%) of the nasopharynx. All the children were treated with methotrexate, vincristine, cyclophosphamide, doxorubicin, and cytarabine. The mortality of the children with BL in this study population was related to longer duration of clinical manifestations and also misdiagnosis before getting the final diagnosis of BL.

Conclusions
Paediatric patients with primary nasopharyngeal BL have an excellent survival rate. Early diagnosis and prompt treatment improve the prognosis of nasopharyngeal BL.