eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
Current issue Archive About the journal Supplements Abstracting and indexing Contact Instructions for authors
SCImago Journal & Country Rank

vol. 15
Original paper

Primary pulmonary sarcoma – long-term treatment outcomes and prognostic factors

Janusz Gołota, Karolina Osowiecka, Tadeusz Orłowski

Kardiochirurgia i Torakochirurgia Polska 2018; 15 (3): 162-169
Online publish date: 2018/09/24
View full text
Get citation
JabRef, Mendeley
Papers, Reference Manager, RefWorks, Zotero
Primary pulmonary sarcoma (PPS) is a rare type of non-epithelial malignant tumour of the lungs. Lung sarcomas are usually of metastatic character, originating from the primary tumour located in another organ. Pathomorphological diagnosis is difficult and therefore definitive diagnosis is usually determined after surgical treatment. Five-year survival of radical operated patients is 42–69%.

To evaluate prognostic factors in PPS.

Material and methods
Twenty-two patients who underwent surgical treatment between 1994 and 2009 were analysed.

Ten types of sarcomas were identified. All 22 analysed patients underwent operations and in 14 (63.6%) cases it was R0 resection (pneumonectomies, lobectomies, non-anatomical resections). In 8 out of 22 patients a locally advanced form was identified. Median overall survival (OS) in the group of all patients was 22 months, 5- and 10-year OS was 27% and 18% respectively, whereas in patients who underwent non-anatomical lung resections it was 80% and 60% respectively with median OS of 213 months. Overall survival was dependent on gender, completeness of treatment and size of tumour. Haemoptysis was a poor prognostic factor. Primitive neuroectodermal tumour was a type of sarcoma with a negative effect on progression-free survival. No impact of age, type of sarcoma, degree of histological malignancy, stage or adjuvant treatment on OS was noted.

Primary radical surgical resection prolongs patient survival. Patients with tumours larger than 5 cm and men have worse prognoses. Future studies conducted on larger groups of patients diagnosed with PPS are necessary.


primary pulmonary sarcoma, surgery, overall survival, prognostic factors

Shields TW, Robinson PC. Uncommon primary malignant tumors of the lung. In: General Thoracic surgery. Shields TW. 5th ed. LW & W, 2000.
Dail DH. Uncommon tumors, sarcomas. In: Pulmonary Pathology: Tumors. Dail DH, Hammar SP, Colby TV (eds.). Springer, New York 1995; 265-293.
Suster S. Primary sarcomas of the lung. Semin Diagn Pathol 1995; 12: 140-157.
Miettinen M. Modern Soft Tissue Pathology, Tumors and NonNeoplastic Conditions. University Press, Cambridge 2010.
Martini N, Hajdu SI, Beattie EJ. Primary sarcoma of the lung. J Thorac Cardiovasc Surg 1971; 61: 33-38.
Guccion JG, Rosen SH. Bronchopulmonary leiomyosarcoma and fibrosarcoma: a study of 32 cases and review of the literature. Cancer 1972; 30: 836-847.
Porte HI, Metois DG, Leroy X, Conti M, Gosselin B, Wurtz A. Surgical treatment of primary sarcoma of the lung. Eur J Cardiothorac Surg 2000; 18: 136-142.
McCormack PM, Martini M. Primary sarcomas and lymphomas of the lung. In: Thoracic Surgery: Frontiers and Uncommon Neoplasms. Martini N, Vogt-Moykopf I. CV Mosby, St. Louis 1989; 261-283.
Nascimento AG, Unni KK, Bernatz PE. Sarcomas of the lung. Mayo Clin Proc 1982; 57: 355-359.
Janssen JP, Mulder JJS, Wagenaar SS, Elbers HRJ, Van Den Bosch JMM. Primary sarcoma of the lung: a clinical study with long term follow-up. Ann Thorac Surg 1994; 58: 1151-1155.
Regnard JF, Icard P, Guibert L, Thomas de Montpreville V, Magdalenat P, Levasseur P. Prognostic factors and results after surgical treatment of primary sarcomas of the lung. Ann Thorac Surg 1999; 68: 227-231.
Bacha EA, Wright CD, Grillo HC, Wain JC, Moncure A, Keel SB, Donahue DM, Mathisen DJ. Surgical treatment of pulmonary sarcomas. Eur J Cardiothorac Surg 1999; 15: 456-460.
Fletcher CD, Hogendoorn P, Mertens F, Bridge J. WHO Classification of Tumours of Soft Tissue and Bone. 4th ed. IARC Press, Lyon 2013; 9-18.
Bhattacharya D, Datta S, Das A, Halder KC, Chattopadhyay S. Primary pulmonary synovial sarcoma: a case report and review of literature. Int J Appl Basic Med Res 2016; 6: 63-65.
Spraker MB, Bair E, Bair R, Connell PP, Mahmood U, Koshy M. An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. J Thorac Oncol 2013; 8: 147-151.
Wu YC, Wang LS, Chen W, Fahn HJ, Huang MH, Whang-Peng J. Primary pulmonary malignant hemangiopericytoma associated with coagulopathy. Ann Thorac Surg 1997; 64: 841-843.
Fletcher CDM, Rydholm A, Singer S, Sundaram M, Coindre JM. Soft tissue tumours: epidemiology, clinical features, histopathological typing and grading. In: World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK, Mertens F.IARCPress, Lyon 2002; 9-18.
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe