Advances in Interventional Cardiology
eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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1/2026
vol. 22
 
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abstract:
Original paper

Prognostic value of the hemoglobin–albumin– lymphocyte–platelet (HALP) score for long-term mortality after transcatheter aortic valve implantation

Mustafa Ferhat Keten
1
,
Seda Tanyeri Uzel
1
,
Ahmet Karaduman
2
,
Busra Guvendi Sengor
1
,
Cemalettin Yılmaz
3
,
Halit Eminoglu
1
,
Baver Bozan
1
,
Tezel Kovanci
1
,
Ismail Balaban
1
,
Regayip Zehir
1

  1. Department of Cardiology, Koşuyolu High Specialization Training and Research Hospital, Istanbul, Turkey
  2. Emsey Hospital, Department of Cardiology, Istanbul, Turkey
  3. Department of Cardiology, Yalova University School of Medicine, Yalova, Turkey
Adv Interv Cardiol 2026; 22, 1 (83): 70–79
DOI: https://doi.org/10.5114/aic.2026.160251
Online publish date: 2026/03/16
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Introduction
Transcatheter aortic valve implantation (TAVI) is the treatment of choice for severe aortic stenosis in elderly and high-risk patients; however, long-term mortality remains substantial. Conventional surgical risk scores show limited prognostic performance in this population, in whom frailty and impaired nutritional and inflammatory status are common. The hemoglobin–albumin–lymphocyte–platelet (HALP) score integrates these domains, but its prognostic value in TAVI has not been established.

Aim
To evaluate whether the preprocedural HALP score predicts long-term all-cause mortality after TAVI.

Material and methods
This retrospective single-center study included 785 consecutive patients who underwent TAVI between January 2018 and January 2024. HALP scores were calculated from routine laboratory parameters. Clinical, echocardiographic, and procedural data were collected. Independent predictors of mortality were assessed using Cox regression analysis. The optimal HALP cut-off was determined by maximally selected rank statistics, and survival was analyzed using Kaplan–Meier analysis.

Results
During a median follow-up of 21.8 months, 62 (8%) patients died. Non-survivors had significantly lower HALP scores and a higher prevalence of chronic kidney disease and atrial fibrillation. In multivariable analysis, lower HALP scores independently predicted mortality (HR = 0.94; 95% CI: 0.91–0.98; p = 0.002), along with chronic kidney disease and paradoxical low-flow, low-gradient aortic stenosis. A HALP cut-off of 36.82 effectively discriminated long-term survival (log-rank p < 0.0001).

Conclusions
Preprocedural HALP score is an independent predictor of long-term mortality after TAVI and may aid preprocedural risk stratification.

keywords:

transcatheter aortic valve implantation, aortic stenosis, hemoglobin–albumin–lymphocyte–platelet score, inflammation and nutrition, long-term mortality

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