eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
4/2020
vol. 24
 
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abstract:
Original article

Proinflammatory cytokines and colorectal cancer – the impact of the stage

Lyudmila Akhmaltdinova
1
,
Valentina Sirota
1
,
Dmitriy Babenko
1
,
Vera Zhumaliyeva
1
,
Irina Kadyrova
1
,
Mereke Maratkyzy
1
,
Aigerim Ibrayeva
1
,
Olga Avdienko
1

1.
Karaganda Medical University, Karaganda, Kazakhstan
Contemp Oncol (Pozn) 2020; 24 (4): 207–210
Online publish date: 2021/01/04
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Colorectal cancer is one of the most often diagnosed malignant tumors. In Kazakhstan, high incidence of CC is registered along with other oncology diseases. Despite a significant progress in the disease treatment achieved lately, CC is still one of the major reasons of mortality due to oncologic pathologies.

To study the samples MilliplexMap HumanCirculationBiomarker panel in blood serum was used. XMap-based Fluorescence immunoassay was implemented, which comprised magnetic-bead-based simultaneous fluorescence detection of IL-6, IL-8, MIF, FGF-2, SCF, TGF, TNF, TRAIL analytes. Proinflammatory biomarker concentration detection at different CC stages allows to reveal the dynamics of inflammatory response of the organism to tumor and to use them (biomarkers) in further diagnostic and forecast in particular in CC. As a result of our study, it was found that IL-6, which showed the brightest reaction, due to its range of change and considerable shift already in the I stage can be recommended as a component of a complex diagnostic panel. Such markers as FGF2 and MIF also have a role in CC early stage detection.
keywords:

cancer biomarkers, cytokine, colorectal cancer, inflammation, interleukin

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