Purpose: Discussion of a case of adverse effects, like chronic anxiety disorders, following the administration of procaine penicillin.

Case description: After procaine penicillin injection, the patient developed symptoms of the Hoigné syndrome, the most intense of which were dizziness and tinnitus, blurred vision and strong fear of death. Since the acute non-allergic reaction to penicillin occurred, panic disorder with severe somatic symptoms revealed and escalated. Those symptoms resembled the past Hoigné syndrome. Despite the treatment, the patient still reported ailments appearing with varying intensity.

Comment: Psychiatric consequences of a reaction to some medication should be considered. Suitable care to those patients is necessary.