Pterygium as a Potential Ocular Manifestation of Morphea: A Case Report and Pathogenic Hypothesis

Julia Woźna; Paweł Pazdrowski; Celina Helak-Łapaj; Maksymilian Markwitz; Adriana Polańska; Marcin Stopa; Aleksandra Dańczak-Pazdrowska

doi:10.5114/dr.2025.153630

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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5/2025
vol. 112

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Pterygium as a Potential Ocular Manifestation of Morphea: A Case Report and Pathogenic Hypothesis

Julia Woźna

^{1, 2}

,

Paweł Pazdrowski

^{1, 3}

,

Celina Helak-Łapaj

³

,

Maksymilian Markwitz

²

,

Adriana Polańska

⁴

,

Marcin Stopa

³

,

Aleksandra Dańczak-Pazdrowska

²

Doctoral School, Poznan University of Medical Sciences, Poznan, Poland
Department of Dermatology, Poznan University of Medical Sciences, Poznana, Poland
Department of Ophthalmology, Chair of Ophthalmology and Optometry, Poznan University of Medical Sciences, Poznan, Poland
Department of Dermatology and Venerology, Poznan University of Medical Sciences, Poznan, Poland

Dermatol Rev/Przegl Dermatol 2025, 112, 336-339

DOI: https://doi.org/10.5114/dr.2025.153630

Data publikacji online: 2025/12/30

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Metryki PlumX:

Morphea, or localized scleroderma, is a chronic inflammatory condition marked by excessive collagen deposition, resulting in skin thickening and fibrosis. We report the rare case of a 54-year-old woman with en coup de sabre morphea overlapping with progressive facial hemiatrophy, who additionally presented with a pterygium. Systemic immunosuppressive therapy was initiated due to disease progression. The case underscores the importance of multidisciplinary assessment in atypical morphea presentations and raises the question of a potential association between fibrotic ocular pathology such as pterygium and underlying autoimmune connective tissue disease. Recent findings suggest overactivation of the p53 pathway in both morphea and pterygium, potentially linking their fibrotic mechanisms. Further research is warranted to explore this intersection.

Indeks osobowy

Pterygium as a Potential Ocular Manifestation of Morphea: A Case Report and Pathogenic Hypothesis

Julia Woźna 1, 2 , Paweł Pazdrowski 1, 3 , Celina Helak-Łapaj 3 , Maksymilian Markwitz 2 , Adriana Polańska 4 , Marcin Stopa 3 , Aleksandra Dańczak-Pazdrowska 2

Julia Woźna

^{1, 2}

,

Paweł Pazdrowski

^{1, 3}

,

Celina Helak-Łapaj

³

,

Maksymilian Markwitz

²

,

Adriana Polańska

⁴

,

Marcin Stopa

³

,

Aleksandra Dańczak-Pazdrowska

²