eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
1/2018
vol. 22
 
Share:
Share:
more
 
 
abstract:
Case report

Recanalization and remodeling of the great saphenous vein caused by the large melanoma’s cutaneous metastasis

Przemysław Stefaniak, Przemysław Kwiatkowski, Zygmunt Kozielec, Janusz Godlewski

Contemp Oncol (Pozn) 2018; 22 (1): 54-59
Online publish date: 2018/04/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Aim of the study
Large melanoma tumour caused arterial remodelling of the distal part of the great saphenous vein. The metastasis occurred at the site where inguinal lymphadenectomy was previously performed and the proximal part of the great saphenous vein was resected. The aim of this study is the presentation of such a rare observation and literature overview concerning melanoma metastasis and possible stimuli causing remodelling of veins.

Material and methods
Macroscopic and microscopic analyses of the large blood vessel that supplies melanoma were made. The size and structure of the blood vessel was compared with the regular great saphenous vein.

Results
The macroscopic examinations allowed us to ascertain that the blood vessel that was identified intraoperatively as the great saphenous vein, has a thick, stiff wall. The microscopic analysis allowed demonstrated that the tunica media was typical for a muscular artery morphology. The morphometric analysis revealed that the blood vessel wall in the area of metastatic tumour was much thicker than the wall of a regular great saphenous vein.

Conclusions
This malignant melanoma skin metastases caused the recanalisation of the great saphenous vein the lumen of which was obliterated during the initial surgical treatment. The metastatic tumour supplied by large blood vessels grew extensively and caused arterial remodelling of the venous wall.

keywords:

melanoma malignum, melanoma metastases, great saphenous vein remodelling, muscular artery

references:
Ernfors P. Cellular origin and developmental mechanisms during the formation of skin melanocytes. Exp Cell Res 2010; 316: 1397-407.
Lugassy C, Zadran S, Bentolila LA, et al. Angiotropism, pericytic mimicry and extravascular migratory metastasis in melanoma: an alternative to intravascular cancer dissemination. Cancer Microenviron 2014; 7: 139-52.
Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 163-76.
Meier F, Will S, Ellwanger U, Schlagenhauff B, Schittek B, Rassner G, Garbe C. Metastatic pathways and time courses in the orderly progression of cutaneous melanoma. Br J Dermatol 2002; 47: 62-70.
Leiter U, Meier F, Schittek B, Garbe C. The natural course of cutaneous melanoma. J Surg Oncol 2004; 8: 172-8.
Balch CM, Houghton AN, Sober AJ, Soong S. Cutaneous Melanoma. 4th edition. Quality Medical Publishing, St. Louis 2003.
León P, Daly JM, Synnestvedt M, Schultz DJ, Elder DE, Clark WH Jr. The prognostic implications of microscopic satellites in patients with clinical stage I melanoma. Arch Surg 1991; 126: 1461-68.
Coit D, Ferrone C. Recurrent regional metastases of melanoma. In: Cutaneous melanoma. Balch C, Houghton AN, Sober AJ, Soong SJ, Atkins MA, Thompson JF (eds.). 5th ed. Quality Medical Publishing, St Louis 2009; 487-98.
Wilmott J, Haydu L, Bagot M, et al. Angiotropism is an independent predictor of microscopic satellites in primary cutaneous melanoma. Histopathology 2012; 61: 889-98.
Damsky WE, Rosenbaum LE, Bosenberg M. Decoding melanoma metastasis. Cancers 2011; 3: 126-63.
Kaehler KC, Egberts F, Hauschild A. Electrochemotherapy in symptomatic melanoma skin metastases: intraindividual comparison with conventional surgery. Dermatol Surg 2010; 36: 1200-2
Jain RK. Normalization of tumour vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
Vacca A, Ria R, Ribatti D, Bruno M, Dammacco F. Angiogenesis and tumour progression in melanoma. Recenti Prog Med 2000; 91: 581-7.
Ribatti D, Annese T, Longo V. Cancers (Basel). Angiogenesis and melanoma. 2010; 2: 114-32.
Luttun A, Autiero M, Tjwa M, Carmeliet P. Genetic dissection of tumour angiogenesis: are PIGF and VEGFR-1 novel anti-cancer targets? Biochim Biophys Acta 2004; 1654: 79-94.
Muehlenweg B, Sperl S, Magdolen V, Schmitt M, Harbeck N. Interference with the urokinase plasminogen activator system: a promising therapy concept for solid tumours. Expert Opin Biol Ther 2001; 1: 683-91.
Hendrix MJ, Seftor EA, Hess AR, Seftor RE. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 2003; 3: 411-21.
Thies A, Mangold U, Moll I, Schumacher U. PAS positive loops and networks as a prognostic indicator in cutaneous malignant melanoma. J Pathol 2001; 195: 537-42
Easty DJ, Hill SP, Hsu MY, Fallowfield ME, Florenes VA, Herlyn M, Bennett DC. Up-regulation of ephrin-A1 during melanoma progression. Int. J. Cancer 1999; 84: 494-501.
Henderson VJ, Cohen RG, Mitchell RS, et al. Biochemical (functional) adaptation of “arterialized” vein grafts. Ann Surg 1986; 203: 339-45.
Jalali S, Li YS, Sotoudeh M, Yuan S, Li S, Chien S, Shyy JY. Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells. Arterioscler Thromb Vasc Biol 1998; 18: 227-34.
Go YM, Boo YC, Park H, et al. Protein kinase B/Akt activates c-Jun NH(2)-terminal kinase by increasing NO production in response to shear stress. J Appl Physiol 2001; 91: 1574-81.
Shay-Salit A, Shushy M, Wolfovitz E, Yahav H, Breviario F, Dejana E, Resnick N. VEGF receptor 2 and the adherents junction as a mechanical transducer in vascular endothelial cells. Proc Natl Acad Sci U S A 2002; 99: 9462-7.
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe