eISSN: 2084-9885
ISSN: 1896-6764
Neuropsychiatria i Neuropsychologia/Neuropsychiatry and Neuropsychology
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
SCImago Journal & Country Rank
3/2012
vol. 7
 
Share:
Share:
more
 
 
abstract:

Review article
Antidepressant effect of non-pharmacological chronotherapy in the treatment of depression

Magdalena Chojnacka
,
Łukasz Święcicki

Neuropsychiatria i Neuropsychologia 2012; 7, 3: 148–157
Online publish date: 2012/11/20
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Antidepressants are the main treatment for depression. However, application of pharmacotherapy is often connected with some limitations. In the last decades growing evidence has been accumulated pointing to a role of dysregulated biological rhythms in functional pathology of depression. That is why interest in chronobiological interventions is increasing. Chronotherapy is based on the principles of circadian rhythm organization. Chronotherapeutics in depression can be defined as controlled exposure to environmental stimuli that act on biological rhythms in order to achieve the appropriate day-night cycle, as well as restoration and synchronization of neuroendocrinal, physiological and cognitive factors. Chronotherapy for depression includes pharmacological treatment (agomelatine) and nonpharmacological treatments (sleep deprivation, bright light therapy, and sleep phase advance). In this paper nonpharmacological interventions are described. Although these methods are relatively safe, cheap and well-tolerated chronotherapeutics are not widely used. Nevertheless, more and more reports provide evidence for the effectiveness of these treatments in depression.

Furthermore, some modifications of each technique, several integrative chronotherapeutics and combination with medication can be an alternative modality to conventional treatment. This article presents the current knowledge of principles of circadian timing and chronobiological aspects of depression. It also describes methods of chronotherapy, their implementation in everyday practice, and possible adverse effects. Next, integrative chronotherapeutics and combination with medication are presented. This paper reviews studies on effectiveness and tolerability of these interventions.
keywords:

depression, circadian rhythms, chronotherapy

Quick links
© 2021 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe