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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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4/2008
vol. 46
 
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abstract:

Review paper
The role of osteopontin in pathogenesis of arthritis

Kinga Lis

Reumatologia 2008; 46, 4: 240–244
Online publish date: 2008/09/26
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Osteopontin (OPN) is a multifunctional protein which is highly expressed in bone. OPN is also expressed by various tissues and many cell types like macrophages, chondrocytes, epithelial cells, endothelial cells and smooth muscle. Osteopontin is involved in many biological processes, equal physiological as well as pathological, in multiple diverse tissues and organs. This protein participates in biomineralization, inflammation, leukocyte activation, migration and adhesion many type of cells. Osteopontin is an important factor, which can present due to abilities in development osteoarthritis and rheumatoid arthritis
keywords:

osteopontin, osteoarthritis, rheumatoid arthritis




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