eISSN: 1896-9151
ISSN: 1734-1922
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vol. 5

Breast cancer risk not only was not associated with CYP17/A2 allele but also was related to A1 allele

Mojgan Hosseini
Massoud Houshmand
Ahmad Ebrahimi

Arch Med Sci 2009; 5, 1: 103-106
Online publish date: 2009/04/22
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Introduction: Breast cancer is the second most common cancer in the world and the most common cancer in Iranian women in terms of rate. The cytochrome P-450c17a (CYP17) gene, located on chromosome 10q24.3, encodes the enzyme cytochrome P-450c17a, which functions as a susceptibility factor in breast cancer.
Material and methods: Three common polymorphisms have been described in the CYP17 gene. The variant creates a recognition site for the MspAI restriction enzyme, the common allele as A1 and the variant alleles A2 (–34T ® C). In total 53 Iranian sporadic breast cancer affected women compared to the control group were studied by PCR-RFLP for CYP17 variant.
Results: Even though the A2/A2 were reported as risk factors for breast cancer our results showed that the A1/A1 were a higher risk factor in our population. A2/A2 had an inhibitory effect in our patients [A1/A1 / A2/A2 odds ratio, 5.57 (95% confidence interval, 1.514-20.506) p = 0.008].
Conclusions: We conclude that not only was A2/A2 in our patients not associated with breast cancer risk but also there is a reverse relation between presence of A1/A1 and increase of breast cancer risk.

CYP17 gene, polymorphism, breast cancer, MSPA1, PCR-RFLP, susceptibility factor

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