eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
2/2022
vol. 39
 
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abstract:
Original paper

Scalp vascularization as a marker of topical minoxidil treatment efficacy in patients with androgenetic alopecia

Karolina Kozicka
1
,
Adriana Łukasik
1
,
Maciej Pastuszczak
1
,
Grzegorz Dyduch
2
,
Agata Kłosowicz
1
,
Anna Wojas-Pelc
1

1.
Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland
2.
Department of Pathomorphology, Jagiellonian University Medical College, Krakow, Poland
Adv Dermatol Allergol 2022; XXXIX (2): 316-320
Online publish date: 2021/02/19
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Introduction
Androgenetic alopecia is the most common type of non-cicatricial hair loss both in male and female patients. The pathomechanism of the disease involves chronic and progressive miniaturization of hair follicles, which leads to the conversion of terminal hair to vellus hair. Minoxidil is a first-line drug in the treatment of female pattern hair loss (FPHL). The study is aimed at verifying whether the degree of scalp vascularization has an impact on the efficacy of topical 5% minoxidil treatment.

Material and methods
The study involved a group of 76 patients diagnosed with FPHL, who underwent a scalp biopsy for a histological examination of their scalp vascularization. The patients were divided into two groups, with rich and poor scalp vasculature. In all patients, topical treatment with 5% minoxidil was applied for a minimum of 6 months, followed by video-trichoscopic assessment.

Results
A significant increase in the total count was observed 6 months into the treatment as compared with baseline, and a decrease in the number of single hair per follicle. It was observed that the number of single hair units had gone down in 50.67% of patients. The study also demonstrated an increase in the total hair count in 57.33% of patients as well as no drops in the total count in 68% of patients, following 6 months of treatment.

Conclusions
Patients responded equally well to the applied topical minoxidil treatment, irrespectively of the number of blood vessels in the scalp.

keywords:

FPHL, minoxidil, video trichoscopy, hair disorder

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