The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7

Anna Starzyńska; Aleksandra Sejda; Łukasz Adamski; Paulina Adamska; Rafał Pęksa; Monika Sakowicz-Burkiewicz; Piotr Wychowański; Barbara A. Jereczek-Fossa

doi:10.5114/ada.2020.98523

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7

Anna Starzyńska

¹

,

Aleksandra Sejda

²

,

Łukasz Adamski

¹

,

Paulina Adamska

¹

,

Rafał Pęksa

³

,

Monika Sakowicz-Burkiewicz

⁴

,

Piotr Wychowański

⁵

,

Barbara A. Jereczek-Fossa

^{6, 7}

Department of Oral Surgery, Medical University of Gdansk, Gdansk, Poland

Department of Pathomorphology, University of Warmia and Mazury, Olsztyn, Poland

Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland

Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland

Department of Oral Surgery, Medical University of Warsaw, Warsaw, Poland

Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy

Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy

Adv Dermatol Allergol

DOI: https://doi.org/10.5114/ada.2020.98523

Online publish date: 2020/10/13

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AMA

Starzyńska A, Sejda A, Adamski Ł, et al. The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7. Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology. 2020. doi:10.5114/ada.2020.98523.

APA

Starzyńska, A., Sejda, A., Adamski, Ł., Adamska, P., Pęksa, R.,  & Sakowicz-Burkiewicz, M. et al. (2020). The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7. Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology. https://doi.org/10.5114/ada.2020.98523

Chicago

Starzyńska, Anna, Aleksandra Sejda, Łukasz Adamski, Paulina Adamska, Rafał Pęksa, Monika Sakowicz-Burkiewicz,  and Piotr Wychowański et al. 2020. "The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7". Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology. doi:10.5114/ada.2020.98523.

Harvard

Starzyńska, A., Sejda, A., Adamski, Ł., Adamska, P., Pęksa, R., Sakowicz-Burkiewicz, M., Wychowański, P.,  and Jereczek-Fossa, B. (2020). The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7. Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology. https://doi.org/10.5114/ada.2020.98523

MLA

Starzyńska, Anna et al. "The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7." Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology, 2020. doi:10.5114/ada.2020.98523.

Vancouver

Starzyńska A, Sejda A, Adamski Ł, Adamska P, Pęksa R, Sakowicz-Burkiewicz M et al. The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7. Postępy Dermatologii i Alergologii/Advances in Dermatology and Allergology. 2020. doi:10.5114/ada.2020.98523.

Introduction
The most common malignant neoplasm of the oral cavity is squamous cell carcinoma. It accounts for over 95% of malignant lesions in this area and is characterised by rapid spread and distant metastases.

Aim
To collect and review the data on B7 family proteins as prognostic factors in oral squamous cell carcinoma and to describe their role in aggressive disease progression.

Material and methods
A systematic review of the literature about B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7, was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 articles published before 22 May 2020 were included in the systematic review.

Results
The biggest study group consisted of 201 patients and the smallest – 40 patients. B7-1, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7 protein expressions were prognostic factors. Overall survival was significantly associated with B7-H3, B7-H5, B7-H6 and B7-H7. Immunohistochemistry was the diagnostic method used in all the studies.

Conclusions
The data presented indicate the complexity of cellular and molecular processes related to the formation, development and invasion of oral cancer. Mutations in genes encoding the B7 family and changes in the B7 protein pathway may affect the prognosis of survival in patients with oral squamous cell carcinoma.

keywords:

The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7

Anna Starzyńska 1 , Aleksandra Sejda 2 , Łukasz Adamski 1 , Paulina Adamska 1 , Rafał Pęksa 3 , Monika Sakowicz-Burkiewicz 4 , Piotr Wychowański 5 , Barbara A. Jereczek-Fossa 6, 7

squamous cell carcinoma, oral cavity, B7 antigens

Anna Starzyńska

¹

,

Aleksandra Sejda

²

,

Łukasz Adamski

¹

,

Paulina Adamska

¹

,

Rafał Pęksa

³

,

Monika Sakowicz-Burkiewicz

⁴

,

Piotr Wychowański

⁵

,

Barbara A. Jereczek-Fossa

^{6, 7}