eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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Original paper

The B7 family molecules in oral squamous cell carcinoma: a systematic review. Part II: B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7

Anna Starzyńska
Aleksandra Sejda
Łukasz Adamski
Paulina Adamska
Rafał Pęksa
Monika Sakowicz-Burkiewicz
Piotr Wychowański
Barbara A. Jereczek-Fossa
6, 7

  1. Department of Oral Surgery, Medical University of Gdansk, Gdansk, Poland
  2. Department of Pathomorphology, University of Warmia and Mazury, Olsztyn, Poland
  3. Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland
  4. Department of Molecular Medicine, Medical University of Gdansk, Gdansk, Poland
  5. Department of Oral Surgery, Medical University of Warsaw, Warsaw, Poland
  6. Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, Milan, Italy
  7. Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy
Adv Dermatol Allergol
Online publish date: 2020/10/13
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The most common malignant neoplasm of the oral cavity is squamous cell carcinoma. It accounts for over 95% of malignant lesions in this area and is characterised by rapid spread and distant metastases.

To collect and review the data on B7 family proteins as prognostic factors in oral squamous cell carcinoma and to describe their role in aggressive disease progression.

Material and methods
A systematic review of the literature about B7-1, B7-2, B7-H2, B7-H3, B7-H4, B7-H5 (VISTA), B7-H6 and B7-H7, was carried out, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. 9 articles published before 22 May 2020 were included in the systematic review.

The biggest study group consisted of 201 patients and the smallest – 40 patients. B7-1, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7 protein expressions were prognostic factors. Overall survival was significantly associated with B7-H3, B7-H5, B7-H6 and B7-H7. Immunohistochemistry was the diagnostic method used in all the studies.

The data presented indicate the complexity of cellular and molecular processes related to the formation, development and invasion of oral cancer. Mutations in genes encoding the B7 family and changes in the B7 protein pathway may affect the prognosis of survival in patients with oral squamous cell carcinoma.


squamous cell carcinoma, oral cavity, B7 antigens

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