1. Wilkinson L, Gathani T. Understanding breast cancer as a global health concern. Br J Radiol 2022; 95: 20211033.
2.
Yang J, Ju J, Guo L, et al. Prediction of HER2-positive breast cancer recurrence and metastasis risk from histopathological images and clinical information via multimodal deep learning. Comput Struct Biotechnol J 2022; 20: 333-342.
3.
Tapia M, Hernando C, Martínez MT, et al. Clinical impact of new treatment strategies for HER2-positive metastatic breast cancer patients with resistance to classical anti-HER therapies. Cancers (Basel) 2022; 15: 4522.
4.
Vernieri C, Milano M, Brambilla M, et al. Resistance mechanisms to anti‑HER2 therapies in HER2‑positive breast cancer: current knowledge, new research directions and therapeutic perspectives. Crit Rev Oncol Hematol 2019; 139: 53-66.
5.
Geng W, Thomas H, Chen Z, et al. Mechanisms of acquired resistance to HER2-positive breast cancer therapies induced by HER3: A comprehensive review. Eur J Pharmacol 2024; 977: 176725.
6.
Xu L, Han F, Zhu L, et al. Advances in understanding the role and mechanisms of tumor stem cells in HER2-positive breast cancer treatment resistance. Int J Oncol 2023; 62: 48.
7.
Liu J, Meng Z, Yidan X. Cardiotoxicity of HER2-targeted drugs when combined with other drugs: a systematic and meta-analysis of randomized controlled trials. Cardiovasc Toxicol 2024; 24: 757-765.
8.
Low JL, Wong RSJ, Chan ZY, Lee SC. Health care policies, drug costs, and time toxicities in biologics for HER2‑positive breast cancer: cost minimization analysis of direct and indirect costs. ESMO Real World Data Dig Oncol 2025; 100121.
9.
Nassar E. Synthesis, (in vitro) antitumor and antimicrobial activity of some pyrazoline, pyridine, and pyrimidine derivatives linked to indole moiety. J Am Sci 2010; 6: 338-347.
10.
Yusuf M, Jain P. Synthetic and biological studies of pyrazolines and related heterocyclic compounds. Arab J Chem 2014; 7: 553-596.
11.
Kumari P, Mishra VS, Narayana C, et al. Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents. Sci Rep 2020; 10: 6660.
12.
Wang H, Zheng J, Xu W, et al. A new series of cytotoxic pyrazoline derivatives as potential anticancer agents that induce cell cycle arrest and apoptosis. Molecules 2017; 22: 1635.
13.
Matiadis D, Sagnou M. Pyrazoline hybrids as promising anticancer agents: an up-to-date overview. Int J Mol Sci 2020; 21: 5507.
14.
Satria D, Waruwu SB, Sholikhah EN, et al. In silico study of anticancer activity of pyrazoline C and M as potential selective of cyclooxygenase-2 (COX-2) inhibitor using molecular docking and MD simulations. Int J App Pharm 2024; 16: 1-5.
15.
Suma AAT, Wahyuningsih TD, Mustofa M. Synthesis, cytotoxicity evaluation and molecular docking study of N-phenylpyrazoline derivatives. Indones J Chem 2019; 19: 1081-1090.
16.
Chaudhary M, Kumar N, Baldi A, et al. 4-Bromo-4’-chloro pyrazoline analog of curcumin augmented anticancer activity against human cervical cancer, HeLa cells: in silico -guided analysis, synthesis, and in vitro cytotoxicity. J Biomol Struct Dyn 2020; 38: 1335-1353.
17.
Mustofa, Satriyo PB, Suma AAT, et al. A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells. Drug Des Devel Ther 2022; 16: 23250-2339.
18.
Ahmed NM, Youns M, Soltan MK, et al. Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma. J Enzyme Inhib Med Chem 2019; 34: 1110-1120.
19.
Sever B, Altıntop MD, Tilki EK, et al. Antiproliferative Effects of a Series of Pyrazolines on Lung Cancer. Proceedings 2018; 2: 1574.
20.
Satriyo PB, Mustofa M, Wahyuningsih TD, et al. N-phenyl pyrazoline derivative inhibits cell aggressiveness and enhances paclitaxel sensitivity of triple negative breast cancer cells. Sci Rep 2024; 14: 13200.
21.
Wahyuningsih TD, Suma AAT, Astuti E. Synthesis, anticancer activity, and docking study of N-acetyl pyrazolines from veratraldehyde. J Appl Pharm Sci 2019; 9: 14-20.
22.
Rana M, Arif R, Khan FI, et al. Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies. Bioorg Chem 2021; 108: 104665.
23.
Wiraswati HL, Bashari MH, Alfarafisa NM, et al. Pyrazoline B-Paclitaxel or Doxorubicin Combination Drugs Show Synergistic Activity Against Cancer Cells: In silico Study. Adv Appl Bioinform Chem 2024; 17: 33-46.
24.
Wiraswati HL, Bashari MH, Alfarafisa NM, et al. Virtual screening of anticancer activity of chalcones and pyrazolines as potential EGFR, VEGFR, and cytochrome P450 inhibitors. J Pharm Pharmacogn Res 2023; 11: 699-713.
25.
Satria D, Waruwu SB, Sholikhah EN, et al. In-silico analysis of n-phenyl pyrazoline derivates as potential of human epidermal growth receptor-2 (HER-2) inhibitor using molecular docking and MD simulations. Rasayan J Chem 2024; 17: 2.
26.
Hasibuan PAZ, Sitorus RKUAB, Hermawan A, et al. Anticancer activity of the ethylacetate fraction of Vernonia amygdalina Delile towards overexpression of HER-2 breast cancer cell lines. Pharmacia 2024; 71: 1-8.
27.
Satria D, Hasibuan PAZ, Muhammad M, et al. Cytotoxic and apoptotic effect of Vernonia amygdalina Delile. fractions against Hs578t triple-negative breast cancer cell lines. Phytomedicine Plus 2024; 4: 2667-0313.
28.
Chatri M, Hasibuan PAZ, Meiyanto E, et al. Effect of african leaves (Vernonia amygdalina Delile) on the development of T47D breast cancer cells. Trop J Nat Prod Res 2024; 8: 7740-7746.
29.
Satria D, Silalahi J, Haro G, et al. Chemical analysis and cytotoxic activity of N-hexane fraction of Zanthoxylum acanthopodium DC. fruits. Rasayan J Chem 2019; 12: 803-808.
30.
Inceler N, Yilmaz A, Baytas SN. Synthesis of ester and amide derivatives of 1-phenyl-3-(thiophen-3-yl)-1H- pyrazole-4-carboxylic acid and study of their anticancer activity. Med Chem Res 2013; 22: 3109-3118.
31.
Zuo MY, Chen LJ, Jiang H, et al. Detecting endotoxin with a flow cytometry-based magnetic aptasensor. Anal Biochem 2014; 466: 38-43.
32.
Ruzinova MB, Benezra R, Id proteins in development, cell cycle and cancer. Trends Cell Biol 2003: 13: 410-418.
33.
Chen Q, Kang J, Fu C. The independence of and associations among apoptosis, autophagy, and necrosis. Sig Transduct Target Ther 2018; 3: 18.
34.
Glaviano A, Foo ASC, Lam HY, et al. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Mol Cancer 2023; 22: 138.
35.
Atmaca H, Bozkurt E, Cittan M, et al. Effects of Galium aparine extract on the cell viability, cell cycle and cell death in breast cancer cell lines. J Ethnopharmacol 2016; 186: 305-310.
36.
Hsin IL, Shen HP, Chang HY, et al. Suppression of PI3K/Akt/mTOR/c-Myc/mtp53 positive feedback loop induces cell cycle arrest by dual PI3K/mTOR Inhibitor PQR309 in endometrial cancer cell lines. Cells. 2021; 10: 2916.
37.
Luo L, Sun X, Yang Y, et al. A novel dual PI3K/mTOR inhibitor, XIN-10, for the treatment of cancer. Int J Mol Sci 2023; 24: 14821.
38.
Forrester SJ, Kikuchi DS, Hernandes MS, et al. Reactive oxygen species in metabolic and inflammatory signaling. Circ Res 2018; 122: 877-902.
39.
Arfin S, Jha NK, Jha SK, et al. Oxidative stress in cancer cell metabolism. Antioxidants 2021; 10: 642.
40.
Beckhauser TF, Francis-Oliveira J, De Pasquale R. Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity. J Exp Neurosci 2016; 23-48.
41.
Herb M, Gluschko A, Schramm M. Reactive Oxygen Species: Not Omnipresent but Important in Many Locations. Front Cell Dev Biol 2021; 9: 1-12.
42.
Meisel RP, Asgari D, Schlamp F, et al. Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex. G3 Genes, Genomes, Genet 2022; 12.
43.
Nguyen PL, Lee CH, Lee H, Cho J. Induction of paraptotic cell death in breast cancer cells by a novel Pyrazolo[3,4-h]quinoline derivative through ROS production and endoplasmic reticulum stress. Antioxidants 2022; 11: 117.