The analysis of CYP19 and COMT gene polymorphism and serum sex hormone levels

Krzysztof Szyłło; Beata Smolarz; Hanna Romanowicz-Makowska; Karolina Przybyłowska; Bartosz Kulig

ISSN: 1231-6407

Ginekologia Praktyczna - - - ARCHIVAL

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2/2006
vol. 14

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abstract:

The analysis of CYP19 and COMT gene polymorphism and serum sex hormone levels

Krzysztof Szyłło

,

Beata Smolarz

,

Hanna Romanowicz-Makowska

,

Karolina Przybyłowska

,

Bartosz Kulig

Gin Prakt 2006; 88: 2: 24-27

Online publish date: 2006/06/19

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Purpose: Women with high circulating estrogen concentrations have an increased risk of breast, endometrium and ovarian cancer, thus it is important to identify factors, including enviromental and genetic variability that maybe alter estrogen concentration.
Patients and methods: We examined associations between Arg264Cys polymorphism of CYP19 gene and Val158Met polymorphism of COMT gene and serum concentrations of estradiol and progesteron in 32 women of reproductive age, who were not taking a hormone therapy.
Results: We did not find significant differences (P > 0.05) between sex hormone concentration and investigated polymorphism.
Conclusions: This result indicated there was no association between investigated polymorphism of CYP19 and COMT genes on the concentration of sex hormone in women of reproductive age, but additional studies with larger groups of subjects are needed to confirm these findings.

keywords:

The analysis of CYP19 and COMT gene polymorphism and serum sex hormone levels

Krzysztof Szyłło , Beata Smolarz , Hanna Romanowicz-Makowska , Karolina Przybyłowska , Bartosz Kulig

CYP19, COMT, gene polymorphism, hormone levels

Krzysztof Szyłło

,

Beata Smolarz

,

Hanna Romanowicz-Makowska

,

Karolina Przybyłowska

,

Bartosz Kulig