The efficacy of metformin for the treatment of psoriasis: a meta-analysis study

Zhuo Huang; Jianhua Li; Hongbo Chen; Dan Yu; Shuwen Sun

doi:10.5114/ada.2023.130524

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

The efficacy of metformin for the treatment of psoriasis: a meta-analysis study

Zhuo Huang

^{1, 2, 3}

,

Jianhua Li

^{1, 2}

,

Hongbo Chen

^{1, 2, 3}

,

Dan Yu

^{1, 2, 3}

,

Shuwen Sun

^{1, 2}

Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China
Department of Medical Genetics, West China Second University Hospital, Sichuan University, Chengdu, China

Adv Dermatol Allergol 2023; XL (5): 606-610

DOI: https://doi.org/10.5114/ada.2023.130524

Online publish date: 2023/08/22

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Introduction and aim:
Metformin has potential in treating patients with psoriasis, and this meta-analysis aims to explore the impact of metformin supplementation on treatment efficacy for psoriasis.

Material and methods:
The PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials (RCTs) assessing the effect of metformin on treatment efficacy for patients with psoriasis.

Results:
Three RCTs were included in the meta-analysis. Overall, compared with control intervention for psoriasis, metformin intervention resulted in significantly increased psoriasis area severity index (PASI) 75% reduction (odds ratio (OR) = 22.02; 95% confidence interval (CI): 2.12 to 228.49; p = 0.01), and erythema, scaling and induration (ESI) 75% reduction (OR = 9.12; 95% CI: 2.13 to 39.02; p = 0.003), and was associated with substantially decreased fasting plasma glucose (FPG, standard mean difference (SMD) = –0.59; 95% CI: –0.92 to –0.26; p = 0.0005), triglycerides (SMD = –0.92; 95% CI: –1.38 to –0.47; p < 0.0001), total cholesterol (SMD = –0.77; 95% CI: –1.22 to –0.32; p = 0.00008), and low-density lipoprotein (LDL, SMD = –0.67; 95% CI: –1.12 to –0.23; p = 0.003).

Conclusions:
Metformin supplementation effectively improves treatment efficacy and metabolic syndrome in psoriasis patients.

keywords:

The efficacy of metformin for the treatment of psoriasis: a meta-analysis study

Zhuo Huang 1, 2, 3 , Jianhua Li 1, 2 , Hongbo Chen 1, 2, 3 , Dan Yu 1, 2, 3 , Shuwen Sun 1, 2

psoriasis, metformin supplementation, treatment efficacy, meta-analysis

Zhuo Huang

^{1, 2, 3}

,

Jianhua Li

^{1, 2}

,

Hongbo Chen

^{1, 2, 3}

,

Dan Yu

^{1, 2, 3}

,

Shuwen Sun

^{1, 2}