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Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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vol. 35
Original paper

The importance of specific IgE antibodies in epidemiology of allergic rhinitis and asthma – the Epidemiology of Allergic Diseases in Poland (ECAP) survey: part one. Influence of allergy risk factors on concentration of specific IgE antibodies in serum

Andrzej Namysłowski, Bolesław K. Samoliński, Agnieszka Lipiec, Wojciech Zieliński, Adam J. Sybilski, Artur Walkiewicz, Piotr Samel-Kowalik, Krzysztof Samoliński, Filip Raciborski

Adv Dermatol Allergol 2018; XXXV (5): 520-526
Online publish date: 2017/10/25
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Specific immunoglobulins E (sIgE) are important parameters to estimate severity of allergic diseases.

To determine the influence of allergy risk factors on the concentration of specific IgE antibodies in serum.

Material and methods
The concentration of sIgE antibodies against allergens Dermatophagoides pteronyssinus, cat dander, timothy grass, Alternaria alternata were determined in serum of 4077 respondents randomly selected from 9 regions (ECAP study). The positive results of sIgE (≥ 0.35 IU/ml) were correlated to answers in questionnaires ECRHSII and ISAAC.

sIgE are more frequently detected in respondents declaring an allergic disease of a father than of a mother (D. pteronyssinus p < 0.05, A. alternata p < 0.01). An early beginning to attend school, kindergarten or nursery increases the frequency of sIgE detection (p < 0.05). If the number of children who slept in the same room as a respondent before the respondent was five years old, was lower, sIgE antibodies are more frequently detected (p < 0.05). Relating to: 1) all 4 allergens, sIgE are the most frequently detected in respondents declaring absence of a carpet/rug at home (p < 0.05), 2) cat dander – less frequently detected in respondents who have a cat at home at the age of 1–4 years (p < 0.005).

Carpets/rugs capture a portion of mite, epidermal, mould allergens located at home, wherefore absence of a carpet or rug causes greater stimulation of an immune system by these allergens; as a consequence, IgE antibodies are the most frequently detected in respondents. Household contacts of the respondents, at the age of 1–4 years, with cats induced partial immune tolerance to cat dander.


specific immunoglobulins E, allergy, epidemiology, ECAP

European Allergy White Paper, The UCB Institute of Allergy. Allergic diseases as a public health problem in Europe. UCB Institute of Allergy. Brussels, Belgium 1997.
Leynaert B, Neukirch C, Kony S, et al. Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004; 113: 86-93.
Bousquet J, Schünemann HJ, Samolinski B, et al. Allergic rhinitis and its impact on asthma (ARIA): achievements in 10 years and future needs. J Allergy Clin Immunol 2012; 130: 1049-62.
Van Cauwenberge P, Watelet JB, Van Zele T, et al. Spreading excellence in allergy and asthma: the Gallen Project. Allergy 2005; 60: 858-64.
Samoliński B, Tomaszewska A, Raciborski F. Różnice występowania alergii i astmy w środowisku wiejskim i miejskim w Polsce – badanie ECAP. Medycyna Środowiskowa 2008; 11: 1-7.
Samoliński B, Sybilski A, Raciborski F, et al. Występowanie astmy oskrzelowej u dzieci, młodzieży i młodych dorosłych w Polsce w świetle badania ECAP. Alergia Astma Immunologia 2009; 14: 27-34.
Samoliński B, Sybilski AJ, Raciborski F, et al. Prevalence of rhinitis in Polish population according to the ECAP (Epidemiology of Allergic Disorders in Poland) study. Otolaryngol Pol 2009; 63: 324-30.
Stankiewicz-Choroszucha B, Wawrzyniak Z, Lipiec A, et al. Consequences of smoke inhalation in the “Epidemiology of Allergic Diseases in Poland” project (ECAP). Ann Agric Environ Med 2011; 18: 420-8.
Sybilski AJ, Raciborski F, Lipiec A, et al. Atopic dermatitis is a serious health problem in Poland. Epidemiology studies based on the ECAP study. Postep Derm Alergol 2015; 32: 1-10.
Eriksson NE. Allergy screening with Phadiatop and CAP Phadiatop in combination with a questionnaire in adults with asthma and rhinitis. Allergy 1990; 45: 285-92.
Bousquet J, Khaltaev N, Cruz AA, et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008; 63 Suppl 86: 8-160.
Available at: www.ecap.pl (Access 28.07.2016).
Samoliński B, Raciborski F, Lipiec A, et al. Epidemiologia chorób alergicznych w Polsce (ECAP). Alergologia Polska – Pol J Allergol 2014; 1: 10-18.
Zieliński W. Wybrane testy statystyczne. Fundacja Rozwój SGGW. Warsaw, Poland 1999.
Hensley Alford S, Zoratti E, Peterson EL, et al. Parental history of atopic disease: disease pattern and risk of pediatric atopy in offspring. J Allergy Clin Immunol 2004; 114: 1046-50.
Anderson EL, Evans MD, DaSilva DFG, et al. History of parental allergy and asthma as predictors of allergic sensitization in their offspring. J Allergy Clin Immunol 2006; 117: S155.
Mandhane PJ, Greene JM, Sears MR. Sex differences in effects of breastfeeding on asthma and allergy in relation to parental atopy. J Allergy Clin Immunol 2006; 117: S198.
Lim RH, Kobzik L, Dahl M. Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis. PLoS One 2010; 5: e10134.
Arshad SH, Karmaus W, Raza A, et al. The effect of parental allergy on childhood allergic diseases depends on the sex of the child. J Allergy Clin Immunol 2012; 130: 427-34.
Westman M, Kull I, Lind T, et al. The link between parental allergy and offspring allergic and nonallergic rhinitis. Allergy 2013; 68: 1571-8.
Fuertes E, Standl M, von Berg A, et al. Parental allergic disease before and after child birth poses similar risk for childhood allergies. Allergy 2015; 70: 873-6.
Tranter DC. Indoor allergens in settled school dust: a review of findings. Clin Exp Allergy 2005; 35: 126-36.
Sporik R, Holgate ST, Platts-Mills TAE, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. N Eng J Med 1990; 323: 502-7.
Cole Johnson C, Ownby DR, Havstad SL, Peterson EL. Family history, dust mite exposure in early childhood, and risk for pediatric atopy and asthma. J Allergy Clin Immunol 2004; 114: 105-10.
Brożek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 Revision. J Allergy Clin Immunol 2010; 126: 466-76.
Botezan C, Karamaus W. Does a higher number of siblings protect against the development of allergy and asthma? A review. J Epidemiol Commun Health 2002; 56: 209-17.
Institute-of-Medicine. Indoor Biologic Exposures. In: Clearing the Air. Asthma and Indoor Air Exposures. National Academy Press. Washington, DC 2000.
Celedon JC, Litonjua AA, Ryan L, et al. Exposure to cat allergen, maternal history of asthma, and wheezing in first 5 years of life. Lancet 2002; 360: 781-2.
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