Abstract
1/2006
vol. 14
The influence of oral hormonal supplement therapy on serum gonadotrophins, estrogens, prolactin and growth hormone levels in postmenopausal women with osteopenia
Gin Prakt 2006; 88, 1: 20-27
Online publish date: 2006/03/17
The study group comprised 65 women (52,4±3,6) in the early postmenopausal period with osteopenia, divided into three groups depending on the type and route of administration of the products: I – on transdermal placebo, II – on transdermal hormone replacement therapy, III – on oral hormone adjunctive therapy. We observed serum prolactin and growth hormone levels during 12-mounth therapy had no changed since the study was started in women administrated transdermal HRT. Serum estrogen, estron, PRL and GH concentrations significantly high increased already in 3 mounth treatment during oral hormonal adjunctive therapy. IGF-1 level was decreased in group II (oral rout). In group on transdermal therapy the increase BMD L2–L4 was not significantly higher then in women on oral estrogens.
Keywords
hormone replacement therapy, hormone supplement therapy, osteopenia, hormones
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