Advances in Interventional Cardiology
eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
Current Issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Share:
Share:
Original paper

The predictive value of the triglyceride-glucose index for five-year all-cause mortality differs between patients with acute de novo heart failure and those with acute decompensated chronic heart failure

Peng Zhang
1
,
Yufeng Zhuo
1
,
Yanling Feng
1
,
Hongji Cheng
1

  1. Department of Cardiology, Panyu District He Xian Memorial Hospital, Guangzhou, China
Adv Interv Cardiol
Online publish date: 2025/11/20
Article file
- The predictive value.pdf  [0.55 MB]
Get citation
 
 
1. Scherbakov N, Bauer M, Sandek A, et al. Insulin resistance in heart failure: differences between patients with reduced and preserved left ventricular ejection fraction. Eur J Heart Fail 2015; 17: 1015-21.
2. Jasińska-Gniadzik K, Szwed P, Gasecka A, et al. Haemodynamic monitoring in acute heart failure - what you need to know. Adv Interv Cardiol 2022; 18: 90-100.
3. Liao Y, Zhang R, Shi S, et al. Triglyceride-glucose index linked to all-cause mortality in critically ill patients: a cohort of 3026 patients. Cardiovasc Diabetol 2022; 21: 128.
4. Du T, Yuan G, Zhang M, et al. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance. Cardiovasc Diabetol 2014; 13: 146.
5. Irace C, Carallo C, Scavelli FB, et al. Markers of insulin resistance and carotid atherosclerosis. A comparison of the homeostasis model assessment and triglyceride glucose index. Int J Clin Pract 2013; 67: 665-72.
6. Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab 2010; 95: 3347-51.
7. Cheng H, Huang W, Huang X, et al. The triglyceride glucose index predicts short-term mortality in non-diabetic patients with acute heart failure. Adv Clin Exp Med 2024; 33: 103-10.
8. Banović M, Vasiljević-Pokrajcić Z, Vijisić-Tesić B, et al. Are de novo acute heart failure and acutely worsened chronic heart failure two subgroups of the same syndrome ? Srp Arh Celok Lek 2010; 138: 162-9.
9. Raffaello WM, Henrina J, Huang I, et al. Clinical characteristics of de novo heart failure and acute decompensated chronic heart failure: are they distinctive phenotypes that contribute to different outcomes? Card Fail Rev 2021; 7: e02.
10. Younis A, Mulla W, Goldkorn R, et al. Differences in mortality of new-onset (de-novo) acute heart failure versus acute decompensated chronic heart failure. Am J Cardiol 2019; 124: 554-9.
11. Pranata R, Tondas AE, Yonas E, et al. Differences in clinical characteristics and outcome of de novo heart failure compared to acutely decompensated chronic heart failure – systematic review and meta-analysis. Acta Cardiol 2021; 76: 410-20.
12. Zucker IH, Xiao L, Haack KK. The central renin-angiotensin system and sympathetic nerve activity in chronic heart failure. Clin Sci (Lond) 2014; 126: 695-706.
13. Zhang DY, Anderson AS. The sympathetic nervous system and heart failure. Cardiol Clin 2014; 32: 33-vii.
14. Kim JA, Montagnani M, Koh KK, et al. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006; 113: 1888-904.
15. Zhang J, Gao Z, Yin J, et al. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. J Biol Chem 2008; 283: 35375-82.
16. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J 2021; 42: 3599-726.
17. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-12.
18. Lee DS, Austin PC, Rouleau JL, et al. Predicting mortality among patients hospitalized for heart failure: derivation and validation of a clinical model. JAMA 2003; 290: 2581-7.
19. Hanley AJ, Williams K, Stern MP, et al. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the San Antonio Heart Study. Diabetes Care 2002; 25: 1177-84.
20. Ormazabal V, Nair S, Elfeky O, et al. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol 2018; 17: 122.
21. Laakso M, Kuusisto J. Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol 2014; 10: 293-302.
22. Vlachopoulos C, Dima I, Aznaouridis K, et al. Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals. Circulation 2005; 112: 2193-200.
23. Fukushima A, Kinugawa S, Takada S, et al. Direct renin inhibitor ameliorates insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice. Eur J Pharmacol 2016; 779: 147-56.
24. Scherbakov N, Bauer M, Sandek A, et al. Insulin resistance in heart failure: differences between patients with reduced and preserved left ventricular ejection fraction. Eur J Heart Fail 2015; 17: 1015-21.
25. Paolillo S, Rengo G, Pellegrino T, et al. Insulin resistance is associated with impaired cardiac sympathetic innervation in patients with heart failure. Eur Heart J Cardiovasc Imaging 2015; 16: 1148-53.
26. Liu XC, He GD, Lo K, et al. The triglyceride-glucose index, an insulin resistance marker, was non-linear associated with all-cause and cardiovascular mortality in the general population. Front Cardiovasc Med 2021; 7: 628109.
27. Carlson GL. Insulin resistance and glucose-induced thermogenesis in critical illness. Proc Nutr Soc 2001; 60: 381-8.
28. Presterl E, Staudinger T, Pettermann M, et al. Cytokine profile and correlation to the APACHE III and MPM II scores in patients with sepsis. Am J Respir Crit Care Med 1997; 156: 825-32.
29. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345: 1359-67.
30. Dufour S, Lebon V, Shulman GI, et al. Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans. Am J Physiol Endocrinol Metab 2009; 297: E231-5.
31. Huang R, Wang Z, Chen J, et al. Prognostic value of triglyceride glucose (TyG) index in patients with acute decompensated heart failure. Cardiovasc Diabetol 2022; 21: 88.
32. Lassus JP, Siirilä-Waris K, Nieminen MS, et al. Long-term survival after hospitalization for acute heart failure--differences in prognosis of acutely decompensated chronic and new-onset acute heart failure. Int J Cardiol 2013; 168: 458-62.
33. Butt JH, Fosbøl EL, Gerds TA, et al. Readmission and death in patients admitted with new-onset versus worsening of chronic heart failure: insights from a nationwide cohort. Eur J Heart Fail 2020; 22: 1777-85.
34. Greene SJ, Triana TS, Ionescu-Ittu R, et al. Patients hospitalized for de novo versus worsening chronic heart failure in the United States. J Am Coll Cardiol 2021; 77: 1023-5.
35. O’Connor CM, Stough WG, Gallup DS, et al. Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry. J Card Fail 2005; 11: 200-5.
36. Kurmani S, Squire I. Acute heart failure: definition, classification and epidemiology. Curr Heart Fail Rep 2017; 14: 385-92.
37. Kim SE, Cho DH, Son JW, et al. Impact of NT-proBNP on prognosis of acute decompensated chronic heart failure versus de novo heart failure. Int J Cardiol 2022; 363: 163-70.
38. Xanthopoulos A, Butler J, Parissis J, et al. Acutely decompensated versus acute heart failure: two different entities. Heart Fail Rev 2020; 25: 907-16.
Copyright: © 2025 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2025 Termedia Sp. z o.o.
Developed by Bentus.