eISSN: 2299-551X
ISSN: 0011-4553
Journal of Stomatology
Current issue Archive About the journal Editorial board Subscription Contact Instructions for authors
SCImago Journal & Country Rank
3/2018
 
Share:
Share:
more
 
 
abstract:
Original paper

The relationship between interleukin-18 level in smokers and chronic periodontitis: radiographic overview of posterior mandibular teeth

F.X. Andi Wiyanto, Sri Lelyati C. Masulili, Elza Ibrahim Auerkari, Fatimah Maria Tadjoedin

J Stoma 2018; 71, 3: 254-258
Online publish date: 2018/12/23
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Introduction
Tobacco smoking is a very common addiction worldwide and an environmental factor predisposing to periodontal disease. The role of cytokines and chemokines in chronic periodontitis pathogenesis has been previously confirmed. Evaluating serum cytokines and chemokines is essential in determining inflammatory responses in periodontitis patients. Previous findings imply a close relationship between elevated cytokine interleukin-18 (IL-18) levels and chronic periodontitis pathogenesis in smokers; however, the usefulness of IL-18 as an inflammatory marker in gingivitis remains unclear. The aim of the study was to analyze IL-18 levels in smokers with chronic periodontitis.

Objectives
The purpose of this study was to analyze the relevance of IL-18 levels to the severity of chronic periodontitis in smokers in terms of the radiographic features of mandibular posterior teeth.

Material and methods
A cross-sectional study of 76 male subjects aged 19-34 years with chronic periodontitis in Depok, Indonesia was performed. Clinical data (OHIS, pockets, CAL), smoking status, and IL-18 samples were collected; samples were detected using ELISA.

Results
IL-18 levels in smokers with moderate periodontitis were higher than in those with mild periodontitis. However, the results showed that the differences in IL-18 levels were not significant based on daily cigarette consumption, and no significant correlation was revealed regarding IL-18 concentrations in smokers based on smoking duration. The correlation test results demonstrated a significant relationship between periodontitis severity and the number of cigarettes consumed per day, but no significant correlation between periodontitis severity in smokers and smoking duration.

Conclusions
IL-18 levels in saliva and gingival crevicular fluid can be used as a predictable biomarker for periodontal disease progression, but cannot be used to determine the patients’ smoking habits. Further studies are required to confirm the relationship between IL-18 and chronic periodontitis in smokers.

keywords:

interleukin-18, chronic periodontitis, smokers

references:
Singh GH, Bhardwaj A, Singh Y. Smoking and periodontal disease. J Pharm Sci Innov 2013; 2: 7-13.
Mehta H, Nazzal K, Sadikot RT. Cigarette smoking and innate immunity. Inflamm Res 2008; 57: 497-503.
Abu-Ta’a M. The effects of smoking on periodontal disease: an
evidence-based comprehensive literature review. Open J Stomatol 2014; 4: 33-41.
Marina T, Ioanna T, Maria M, Lazaros T. The effect of smoking on components of gingival crevicular fluid in patients with periodontal disease. Oral Health Dent Manag 2015; 14: 1-5.
Toma V, Cioloca DP, Forna DA, et al. IL 18 as an important gingival inflammatory biochemical marker in children and adolescents with insulin-dependent diabetes mellitus. Rev Chim (Bucharest) 2016; 67: 2545-2551.
Mokeem SA, Vellappally S, Preethanath RS, et al. Influence of smoking on clinical parameters and gingival crevicular fluid volume in patients with chronic periodontitis materials and methods after careful removal of all supragingival plaque, teeth were washed with water spray, isolated with cotton rol. Oral Health Dent Manag 2014; 13: 469-473.
Cetinkaya B, Guzeldemir E, Ogus E, Bulut S. Cytokines in gingival crevicular fluid and serum of patients with rheumatoid. J Perio­dontol 2012; 84: 84-93.
Kulczyk T. Evaluation of the results of periodontal treatment by means of digital subtraction of radiographic images. Adv Med Sci 2006; 51: 126-129.
Jain H, Mulay S. Detrimental effects of smoking on periodontium in health and disease. Int J Sci Study 2014; 2: 76-81.
Tagliacozzo R. Smokers self-categorization and the reduction of cognitive dissonance. Addict Behav 1979; 4: 393-399.
Esfahrood ZR, Zare D, Reza JZ. Levels of interleukin-18 in saliva and gingival crevicular fluid in patients with chronic periodontitis and healthy subjects. Annu Res Rev Biol 2016; 10: 1-6.
Pradeep AR, Hadge P, Chowdhry S, et al. Exploring the role of Th1 cytokines: interleukin-17 and interleukin-18 in periodontal health and disease. J Oral Sci 2009; 51: 261-266.
Nair V, Bandyopadhyay P, Kundu D, Das S. Estimation of inter­leukin-18 in the gingival crevicular fluid and serum of Bengali population with periondontal health and disease. Indian Soc Perio­dontol 2016; 20: 260-264.
Tanaka K, Miyake Y, Hanioka T, Furukawa S. The IL18 promoter polymorphism, rs1946518, is associated with the risk of perio­dontitis in Japanese women: The Kyushu Okinawa Maternal and Child Health Study. Tohoku J Exp Med 2017; 243: 159-164.
FEATURED PRODUCTS
Quick links
© 2019 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe