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eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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2/2009
vol. 47
 
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abstract:
Review paper

The role of OPG/RANKL/RANK in bone destruction in rheumatoid arthritis

Małgorzata Wisłowska
,
Danuta Jakubicz
,
Katarzyna Olczyk-Wrochna

Reumatologia 2009; 47, 2: 67–74
Online publish date: 2009/06/10
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A decrease in bone mineral density (BMD) is common in chronic inflammatory diseases of the musculoskeletal system. So-called “inflammatory osteoporosis” concerns up to 50% of rheumatic patients. Its intensity is relevant to the disease activity and the patient’s age. In rheumatoid arthritis (RA) it is primarily caused by osteoclast activation and its most apparent manifestation is periarticular osteoporosis due to a local inflammatory process. Apart from chronic inflammation RA-related osteoporosis can be caused by glucocorticosteroid (GSS) use and immobilization. In menopausal women hormonal disturbances can contribute to the damage. RA patients are at increased risk of low-energy fractures. The questions are whether it is inflammation per se or GSS that affects bones most in this disease, and whether accelerated bone loss results in increased susceptibility to osteoporotic fractures in RA patients.
keywords:

rheumatoid arthritis, osteoporosis, densytometry examination, bone turnover markers







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