Postępy Psychiatrii i Neurologii

The role of adipokines in the inflammatory theory of depression: mechanisms and therapeutic applications

Aleksandra J. Oracz 1
,
Maria Suprunowicz 1
,
Emilia Turczyńska 1
,
Paulina Grzeszczuk 1
,
Dominika Zarzycka 1
,
Maria Qaheri 1
,
Beata Konarzewska 1

  1. Department of Psychiatry, Medical University of Bialystok, Bialystok, Poland

DOI: https://doi.org/10.5114/ppn.2026.164932
Data publikacji online: 2026/09/22
Plik artykułu
PPiN-00445-The_role.pdf
  1. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010; 316: 129-139.
  2. Gałecki P, Talarowska M. Inflammatory theory of depression. Psychiatr Pol 2018; 52: 437-447.
  3. Young JJ, Bruno D, Pomara N. A review of the relationship between proinflammatory cytokines and major depressive disorder. J Affect Disord 2014; 169: 15-20.
  4. Leo R, Di Lorenzo G, Tesauro M, Cola C, Fortuna E, Zanasi M, et al. Decreased plasma adiponectin concentration in major depression. Neurosci Lett 2006; 407: 211-213.
  5. Hamilton JP, Etkin A, Furman DJ, Lemus MG, Johnson RF, Gotlib IH. Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of base line activation and neural response data. Am J Psychiatry 2012; 169: 693-703.
  6. Anisman H. Inflaming depression. J Psychiatry Neurosci 2011; 36: 291-293.
  7. Raison CL, Capuron L, Miller AH. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27: 24-31.
  8. Maes M, Stevens W, Peeters D, DeClerck L, Scharpe S, Bridts C, et al. A study on the blunted natural killer cell activity in severely depressed patients. Life Sci 1992; 50: 505-513.
  9. Köhler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, et al. Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand 2017; 135: 373-387.
  10. Janelidze S, Mattei D, Westrin Å, Träskman-Bendz L, Brundin L. Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun 2011; 25: 335-339.
  11. Mesquita AR, Correia-Neves M, Roque S, Gil Castro A, Vieira P, Pedrosa J, et al. IL-10 modulates depressive-like behavior. J Psychiatr Res 2008; 43: 89-97.
  12. Ogłodek E. Changes in the serum levels of cytokines: IL-1β, IL-4, IL-8 and IL-10 in depression with and without posttraumatic stress disorder. Brain Sci 2022; 12: 387. DOI: 10.3390/BRAINSCI12030387.
  13. Jia Y, Liu L, Sheng C, Cheng Z, Cui L, Li M, et al. Increased serum levels of cortisol and inflammatory cytokines in people with depression. J Nerv Ment Dis 2019; 207: 271-276.
  14. Hansson PB, Murison R, Lund A, Hammar Å. Cognitive functioning and cortisol profiles in first episode major depression. Scand J Psychol 2015; 56: 379-383.
  15. Amasi-Hartoonian N, Sforzini L, Cattaneo A, Pariante CM. Cause or consequence? Understanding the role of cortisol in the increased inflammation observed in depression. Curr Opin Endocr Metab Res 2022; 24: 100356. DOI: 10.1016/J.COEMR.2022.100356.
  16. Maes M, Scharpé S, Meltzer HY, Cosyns P. Relationships between increased haptoglobin plasma levels and activation of cell-mediated immunity in depression. Biol Psychiatry 1993; 34: 690-701.
  17. Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD. Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls. Brain Behav Immun 2020; 87: 901-909.
  18. Haapakoski R, Mathieu J, Ebmeier KP, Alenius H, Kivimäki M. Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun 2015; 49: 206-215.
  19. Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR. Melatonin – a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 2011; 93: 350-384.
  20. Nobis A, Zalewski D, Waszkiewicz N. Peripheral markers of depression. J Clin Med 2020; 9: 1-54.
  21. Orlikov A, Ryzov I. Caffeine-induced anxiety and increase of kynurenine concentration in plasma of healthy subjects: a pilot study. Biol Psychiatry 1991; 29: 391-396.
  22. Maes M, Verkerk R, Bonaccorso S, Ombelet W, Bosmans E, Scharpé S. Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation. Life Sci 2002; 71: 1837-1848.
  23. Mendlewicz J, Kriwin P, Oswald P, Souery D, Alboni S, Brunello N. Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study. Int Clin Psychopharmacol 2006; 21: 227-231.
  24. Gałecki P, Szemraj J, Bieńkiewicz M, Zboralski K, Gałecka E. Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients. Hum Psychopharmacol 2009; 24: 277-286.
  25. Maes M. Major depression and activation of the inflammatory response system. Adv Exp Med Biol 1999; 461: 25-46.
  26. Stafford L, Berk M. The use of statins after a cardiac intervention is associated with reduced risk of subsequent depression: proof of concept for the inflammatory and oxidative hypotheses of depression? J Clin Psychiatry 2011; 72: 1229-1235.
  27. Katon W, Lin EHB, Kroenke K. The association of depression and anxiety with medical symptom burden in patients with chronic medical illness. Gen Hosp Psychiatry 2007; 29: 147-155.
  28. Fasshauer M, Blüher M. Adipokines in health and disease. Trends Pharmacol Sci 2015; 36: 461-470.
  29. Taylor EB. The complex role of adipokines in obesity, inflammation, and autoimmunity. Clin Sci (Lond) 2021; 135: 731-752.
  30. Taylor VH, Macqueen GM. The role of adipokines in understanding the associations between obesity and depression. J Obes 2010; 2010: 748048. DOI: 10.1155/2010/748048.
  31. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 1995; 270: 26746-26749.
  32. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999; 257: 79-83.
  33. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 1996; 271: 10697-10703.
  34. Park S, Kim DS, Kwon DY, Yang HJ. Long-term central infusion of adiponectin improves energy and glucose homeostasis by decreasing fat storage and suppressing hepatic gluconeogenesis without changing food intake. J Neuroendocrinol 2011; 23: 687-698.
  35. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001; 7: 941-946.
  36. Jung HN, Jung CH. The role of anti-inflammatory adipokines in cardiometabolic disorders: moving beyond adiponectin. Int J Mol Sci 2021; 22: 13529. DOI: 10.3390/IJMS222413529.
  37. Wozniak SE, Gee LL, Wachtel MS, Frezza EE. Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci 2009; 54: 1847-1856.
  38. Ricci R, Bevilacqua F. The potential role of leptin and adiponectin in obesity: a comparative review. Vet J 2012; 191: 292-298.
  39. Thundyil J, Pavlovski D, Sobey CG, Arumugam TV. Adiponectin receptor signalling in the brain. Br J Pharmacol 2012; 165: 313. DOI: 10.1111/J.1476-5381.2011.01560.X.
  40. Joo YH, Lee MW, Son YD, Chang KA, Yaqub M, Kim HK, et al. In vivo cerebral translocator protein (TSPO) binding and its relationship with blood adiponectin levels in treatment-naïve young adults with major depression: a [11C]PK11195 PET study. Biomedicines 2021; 10: 34. DOI: 10.3390/BIOMEDICINES10010034.
  41. Machado-Vieira R, Gold PW, Luckenbaugh DA, Ballard ED, Richards EM, Henter ID, et al. The role of adipokines in the rapid antidepressant effects of ketamine. Mol Psychiatry 2017; 22: 127-133.
  42. Yaua SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, et al. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proc Natl Acad Sci U S A 2014; 111: 15810-15815.
  43. Liu J, Guo M, Zhang D, Cheng SY, Liu M, Ding J, et al. Adiponectin is critical in determining susceptibility to depressive behaviors and has antidepressant-like activity. Proc Natl Acad Sci U S A 2012; 109: 12248-12253.
  44. Zhang D, Guo M, Zhang W, Lu XY. Adiponectin stimulates proliferation of adult hippocampal neural stem/ progenitor cells through activation of p38 mitogen-activated protein kinase (p38MAPK)/glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling cascade. J Biol Chem 2011; 286: 44913-44920.
  45. Kang E, Wen Z, Song H, Christian KM, Ming GL. Adult neurogenesis and psychiatric disorders. Cold Spring Harb Perspect Biol 2016; 8: a019026. DOI: 10.1101/cshperspect.a019026.
  46. Bloemer J, Pinky PD, Govindarajulu M, Hong H, Judd R, Amin RH, et al. Role of adiponectin in central nervous system disorders. Neural Plast 2018; 2018: 4593530. DOI: 10.1155/2018/4593530.
  47. Formolo DA, Cheng T, Yau SY. Adiponectin elicits rapid-antidepressant effects in chronically stressed mice in association with increased glutamatergic activity in the MPFC. Int J Neuropsychopharmacol 2025; 28 (Issue Supplement_1): i78-i79. DOI: https://doi.org/10.1093/ijnp/pyae059.135.
  48. Diniz BS, Teixeira AL, Campos AC, Miranda AS, Rocha NP, Talib LL, et al. Reduced serum levels of adiponectin in elderly patients with major depression. J Psychiatric Res 2012; 46: 1081-1085.
  49. Carvalho AF, Rocha DQC, McIntyre RS, Mesquita LM, Köhler CA, Hyphantis TN, et al. Adipokines as emerging depression biomarkers: a systematic review and meta-analysis. J Psychiatric Res 2014; 59: 28-37.
  50. Oracz AJ, Zwierz M, Naumowicz M, Suprunowicz M, Waszkiewicz N. Relationship between obesity and depression considering the inflammatory theory. Int J Mol Sci 2025; 26: 4966. DOI: https://doi.org/10.3390/ijms26114966.
  51. Jeong HG, Min BJ, Lim S, Kim TH, Lee JJ, Park JH, et al. Plasma adiponectin elevation in elderly individuals with subsyndromal depression. Psychoneuroendocrinology 2012; 37: 948-955.
  52. Hu Y, Dong X, Chen J. Adiponectin and depression: a meta-analysis. Biomed Rep 2015; 3: 38-42.
  53. Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O. Adipokines: biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity. Biofactors 2011; 37: 413-420.
  54. Obradovic M, Sudar-Milovanovic E, Soskic S, Essack M, Arya S, Stewart AJ, et al. Leptin and obesity: role and clinical implication. Front Endocrinol (Lausanne) 2021; 12: 585887. DOI: 10.3389/FENDO.2021.585887.
  55. Faloia E, Camilloni MA, Giacchetti G, Mantero F. Adipose tissue as an endocrine organ? A review of some recent data. Eat Weight Disord 2000; 5: 116-123.
  56. Zhang Y, Chua S. Leptin function and regulation. Compr Physiol 2017; 8: 351-369.
  57. Farooqi IS, O’Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009; 89: 980S-984S. DOI: https://doi.org/10.3945/ajcn.2008.26788C.
  58. La Cava A, Matarese G. The weight of leptin in immunity. Nat Rev Immunol 2004; 4: 371-379.
  59. Lago R, Gómez R, Lago F, Gómez-Reino J, Gualillo O. Leptin beyond body weight regulation – current concepts concerning its role in immune function and inflammation. Cell Immunol 2008; 252: 139-145.
  60. Milaneschi Y, Simmons WK, van Rossum EFC, Penninx BW. Depression and obesity: evidence of shared bio­logical mechanisms. Mol Psychiatry 2019; 24: 18-33.
  61. Waszkiewicz N. The immunoseasonal theory of psychiatric disorders. J Clin Med 2023; 12: 4615. DOI: 10.3390/JCM12144615.
  62. Lee HJ, Kim SH, Kim EY, Lee NY, Yu HY, Kim YS, Ahn YM. Leptin is associated with mood status and metabolic homeostasis in patients with bipolar disorder. Neuropsychobiology 2014; 70: 203-209.
  63. Paul B, Buchholz DR. Minireview: glucocorticoid-leptin crosstalk: role of glucocorticoid-leptin counterregulation in metabolic homeostasis and normal development. Integr Comp Biol 2023; 63: 1127-1139.
  64. Lang UE, Borgwardt S. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem 2013; 31: 761-777.
  65. Ge T, Fan J, Yang W, Cui R, Li B. Leptin in depression: a potential therapeutic target. Cell Death Dis 2018; 9: 1096. DOI: https://doi.org/10.1038/s41419-018-1129-1.
  66. Milaneschi Y, Lamers F, Bot M, Drent ML, Penninx BW. Leptin dysregulation is specifically associated with major depression with atypical features: evidence for a mechanism connecting obesity and depression. Biol Psychiatry 2017; 81: 807-814.
  67. Renna ME, Shrout MR, Madison AA, aremka LM, Alfano CM, Povoski SP, et al. Fluctuations in depression and anxiety predict dysregulated leptin among obese breast cancer survivors. J Cancer Surviv 2021; 15: 847-854.
  68. Sohan M, Qusar MMAS, Shahriar M, Islam SMA, Bhuiyan MA, Islam MR. Association of reduced serum EGF and leptin levels with the pathophysiology of major depressive disorder: A case-control study. PLoS One 2023; 18: e0288159. DOI: https://doi.org/10.1371/journal.pone.0288159.
  69. Milaneschi Y, Sutin AR, Terracciano A, Canepa M, Gravenstein KS, Egan JM, et al. The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology 2014; 42: 1-10.
  70. Kos K, Harte AL, da Silva NF, Tonchev A, Chaldakov G, James S, et al. Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus. J Clin Endocrinol Metab 2007; 92: 1129-1136.
  71. Tsiotra PC, Boutati E, Dimitriadis G, Raptis SA. High insulin and leptin increase resistin and inflammatory cytokine production from human mononuclear cells. Biomed Res Int 2012; 2013: 487081. DOI: 10.1155/2013/487081.
  72. Tripathi D, Kant S, Pandey S, Ehtesham NZ. Resistin in metabolism, inflammation, and disease. FEBS J 2020; 287: 3141-3149.
  73. Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, et al. Resistin induces monocyte–endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J Cell Physiol 2011; 226: 2181-2188.
  74. Brunetti L, Orlando G, Recinella L, Michelotto B, Ferrante C, Vacca M. Resistin, but not adiponectin, inhibits dopamine and norepinephrine release in the hypothalamus. Eur J Pharmacol 2004; 493: 41-44.
  75. Moret C, Briley M. The importance of norepinephrine in depression. Neuropsychiatr Dis Treat 2011; 7 (Suppl 1): 9-13. DOI: 10.2147/NDT.S19619.
  76. Su KZ, Li YR, Zhang D, Yuan JH, Zhang CS, Liu Y, et al. Relation of circulating resistin to insulin resistance in type 2 diabetes and obesity: a systematic review and meta-analysis. Front Physiol 2019; 10: 1399. DOI: 10.3389/FPHYS.2019.01399.
  77. Zaidi SIZ, Shirwany TAK. Relationship of serum resistin with insulin resistance and obesity. J Ayub Med Coll Abbottabad 2015; 27: 552-555.
  78. Cao B, Chen Y, Brietzke E, Cha D, Shaukat A, Pan Z, et al. Leptin and adiponectin levels in major depressive disorder: a systematic review and meta-analysis. J Affect Disord 2018; 238: 101-110.
  79. Benedetti F, Branchi I, Poletti S, Lorenzi C, Bigai G, Colombo C, Zanardi R. Adiponectin predicts poor response to antidepressant drugs in major depressive disorder. Hum Psychopharmacol Clin Exp 2021; 36: e2793. DOI: https://doi.org/10.1002/hup.2793.
  80. Moieni M, Irwin M, Jevtic I, Olmstead R, Breen EC, Eisenberger NI. Sex differences in depressive and socioemotional responses to an inflammatory challenge: implications for sex differences in depression. Neuropsychopharmacology 2015; 40: 1709-1716.
  81. Syk M, Ellström S, Mwinyi J, Schiöth HB, Ekselius L, Ramklint M, Cunningham JL. Plasma levels of leptin and adiponectin and depressive symptoms in young adults. Psychiatry Res 2019; 272: 1-7.
  82. Permoda-Pachuta A, Malewska-Kasprzak M, Skibińska M, Rzepski K, Dmitrzak-Węglarz M. Changes in adipokine, resitin, and BDNF concentrations in treatment-resistant depression after electroconvulsive therapy. Brain Sci 2023; 13: 1358. DOI: https://doi.org/10.3390/brainsci13101358.
  83. Oracz AJ, Zwierz M, Naumowicz M, Modzelewski S, Suprunowicz M, Waszkiewicz N. Linking metabolic disorders and immune system phenomena in schizophrenia: the role of adipose tissue and inflammation. Biomedicines 2025; 13: 2308. DOI: https://doi.org/10.3390/biomedicines13092308.
  84. Scabia G, Barone I, Mainardi M, Ceccarini G, Scali M, Buzzigoli E, et al. The antidepressant fluoxetine acts on energy balance and leptin sensitivity via BDNF. Sci Rep 2018; 8: 1781. DOI: 10.1038/s41598-018-19886-x.
  85. Tavast IM, Solismaa A, Lyytikäinen LP, Mononen N, Moilanen E, Hämäläinen M, et al. Leptin and leptin receptor gene polymorphisms and depression treatment response. Acta Neuropsychiatr 2025; 37: e38. DOI: 10.1017/neu.2024.43.
  86. Weber-Hamann B, Kratzsch J, Kopf D, Lederbogen F, Gilles M, Heuser I, Deuschle M. Resistin and adiponectin in major depression: the association with free cortisol and effects of antidepressant treatment. J Psychiatr Res 2007; 41: 344-350.
  87. Senkus KE, Crowe-White KM, Bolland AC, Locher JL, Ard JD. Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention. Nutr Diabetes 2022; 12: 30. DOI: 10.1038/S41387-022-00207-1.
  88. Furman JL, Soyombo A, Czysz AH, Jha MK, Carmody TJ, Mason BL, et al. Adiponectin moderates antidepressant treatment outcome in the combining medications to enhance depression outcomes randomized clinical trial. Pers Med Psychiatry 2018; 9-10: 1-7.
  89. Kabthymer RH, Saadati S, Lee M, Hariharan R, Feehan J, Mousa A, de Courten B. Carnosine/histidine-containing dipeptide supplementation improves depression and quality of life: systematic review and meta-analysis of randomized controlled trials. Nutr Rev 2025; 83: e54-e64. DOI: 10.1093/NUTRIT/NUAE021.
  90. Brenton JN, Lehner-Gulotta D, Woolbright E, Banwell B, Bergqvist AGC, Chen S, et al. Phase II study of ketogenic diets in relapsing multiple sclerosis: safety, tolerability and potential clinical benefits. J Neurol Neurosurg Psychiatry 2022; 93: 637-644.
  91. Guiotto A, Calderan A, Ruzza P, Borin G. Carnosine and carnosine-related antioxidants: a review. Curr Med Chem 2005; 12: 2293-2315.
  92. Baye E, Ukropec J, de Courten MPJ, Mousa A, Kurdiova T, Johnson J, et al. Carnosine supplementation improves serum resistin concentrations in overweight or obese otherwise healthy adults: a pilot randomized trial. Nutrients 2018; 10: 1258. DOI: 10.3390/NU10091258.
  93. Farimani AR, Hariri M, Azimi-Nezhad M, Borji A, Zarei S, Hooshmand E. The effect of n-3 PUFAs on circulating adiponectin and leptin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Acta Diabetol 2018; 55: 641-652.
  94. Liao Y, Xie B, Zhang H, He Q, Guo L, Subramanieapillai M, et al. Efficacy of omega-3 PUFAs in depression: a meta-analysis. Transl Psychiatry 2019; 9: 190. DOI: 10.1038/S41398-019-0515-5.
  95. Soltani S, Meshkini F, Torabinasab K, Razmpoosh E, Toupchian O, Zeraattalab-Motlagh S, et al. Low fat-diet and circulating adipokines concentrations: a systematic review and meta-analysis of randomized controlled trials. Diabetol Metab Syndr 2025; 17: 152. DOI: 10.1186/s13098-025-01721-9.
  96. Vaghef-Mehrabany E, Ranjbar F, Asghari-Jafarabadi M, Hosseinpour-Arjmand S, Ebrahimi-Mameghani M. Calorie restriction in combination with prebiotic supplementation in obese women with depression: effects on metabolic and clinical response. Nutr Neurosci 2021; 24: 339-353.
  97. Breymeyer KL, Lampe JW, McGregor BA, Neuhouser ML. Subjective mood and energy levels of healthy weight and overweight/obese healthy adults on high-and low-glycemic load experimental diets. Appetite 2016; 107: 253-259.
  98. Muñoz MA, Fíto M, Marrugat J, Covas MI, Schröder H; REGICOR and HERMES investigators. Adherence to the Mediterranean diet is associated with better mental and physical health. Br J Nutr 2009; 101: 1821-1827.
  99. Patsalos O, Keeler J, Schmidt U, Penninx BWJH, Young AH, Himmerich H. Diet, obesity, and depression: a systematic review. J Pers Med 2021; 11: 176. DOI: 10.3390/jpm11030176.
  100. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol (1985) 2005; 98: 1154-1162.
  101. Kelly AS, Steinberger J, Olson TP, Dengel DR. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 2007; 56: 1005-1009.
  102. Golbidi S, Laher I. Exercise induced adipokine changes and the metabolic syndrome. J Diabetes Res 2014; 2014: 726861. DOI: 10.1155/2014/726861.
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