Tocilizumab in refractory adult-onset Still’s disease – case report and review of the literature

Edyta Kasprzyk; Mariusz Puszczewicz; Aleksandra Kołczewska; Honorata Pietrzak-Kaczmarek

eISSN: 2084-9834
ISSN: 0034-6233

Reumatologia/Rheumatology

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3/2012
vol. 50

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abstract:

Case report

Tocilizumab in refractory adult-onset Still’s disease – case report and review of the literature

Edyta Kasprzyk

,

Mariusz Puszczewicz

,

Aleksandra Kołczewska

,

Honorata Pietrzak-Kaczmarek

Reumatologia 2012; 50, 3: 238–242

Online publish date: 2012/06/27

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Adult-onset Still’s disease (AOSD) is an uncommon systemic connective tissue disease, characterized by a typical spiking fever, evanescent rash, arthritis (Fig. 1, 2), hepatosplenomegaly, lymphadenopathy and sore throat. Non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressants are commonly used as therapeutic agents for AOSD, but some patients are refractory to these conventional therapies. A case of a young woman with severe polyarthritis, refractory to corticosteroids and methotrexate, but successfully treated with the humanized monoclonal anti IL-6 receptor antibody tocilizumab is presented.

keywords:

adult-onset Still’s disease, interleukin 6, tocilizumab

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Tocilizumab in refractory adult-onset Still’s disease – case report and review of the literature

Edyta Kasprzyk , Mariusz Puszczewicz , Aleksandra Kołczewska , Honorata Pietrzak-Kaczmarek

adult-onset Still’s disease, interleukin 6, tocilizumab

Edyta Kasprzyk

,

Mariusz Puszczewicz

,

Aleksandra Kołczewska

,

Honorata Pietrzak-Kaczmarek