Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience

Magdalena Jałowska; Marian Dmochowski; Justyna Gornowicz-Porowska; Monika Bowszyc-Dmochowska

doi:10.5114/ada.2023.127644

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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2/2023
vol. 40

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abstract:

Original paper

Treatment-naïve pemphigus patients showing IgG tissue deposits have serum IgG antibodies against desmoglein 1 detected more often than those against desmoglein 3: a monocentre laboratory experience

Magdalena Jałowska

¹

,

Marian Dmochowski

¹

,

Justyna Gornowicz-Porowska

^{1, 2}

,

Monika Bowszyc-Dmochowska

³

Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland

Department and Division of Practical Cosmetology and Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland

Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland

Adv Dermatol Allergol 2023; XL (2): 277-282

DOI: https://doi.org/10.5114/ada.2023.127644

Online publish date: 2023/06/01

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AMA

Jałowska M, Dmochowski M, Gornowicz-Porowska J, Bowszyc-Dmochowska M. Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(2):277-282. doi:10.5114/ada.2023.127644.

APA

Jałowska, M., Dmochowski, M., Gornowicz-Porowska, J.,  & Bowszyc-Dmochowska, M. (2023). Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(2), 277-282. https://doi.org/10.5114/ada.2023.127644

Chicago

Jałowska, Magdalena, Marian Dmochowski, Justyna Gornowicz-Porowska,  and Monika Bowszyc-Dmochowska. 2023. "Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 40 (2): 277-282. doi:10.5114/ada.2023.127644.

Harvard

Jałowska, M., Dmochowski, M., Gornowicz-Porowska, J.,  and Bowszyc-Dmochowska, M. (2023). Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 40(2), pp.277-282. https://doi.org/10.5114/ada.2023.127644

MLA

Jałowska, Magdalena et al. "Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 40, no. 2, 2023, pp. 277-282. doi:10.5114/ada.2023.127644.

Vancouver

Jałowska M, Dmochowski M, Gornowicz-Porowska J, Bowszyc-Dmochowska M. Treatment-naïve pemphigus patients showing IgG tissue
deposits have serum IgG antibodies against desmoglein 1
detected more often than those against desmoglein 3:
a monocentre laboratory experience. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2023;40(2):277-282. doi:10.5114/ada.2023.127644.

Introduction:
Pemphigus is a heterogeneous group of autoimmune acantholytic diseases.

Aim:
To check whether there is a relationship between detecting IgG deposits in the direct immunofluorescence (DIF) and finding IgG antibodies against particular desmoglein (DSG) isoforms in ELISA techniques in patients with pemphigus.

Material and methods:
Single-step DIF for revealing the deposits of IgA, IgM, IgG, IgG1, IgG4 and C3, and monoanalyte ELISAs or the multiplex ELISA were used for diagnosis. The Z test for two independent proportions was used for the statistical analysis.

Results:
We evaluated 19 consecutive treatment-naïve pemphigus patients, who exhibited IgG deposits, accompanied by other types of immunoreactants in various combinations, in DIF. Serum IgG antibodies against DSG1 were detected in 18 patients, whereas serum IgG antibodies against DSG3 were found in 10 patients. The statistical analysis showed that the proportion of anti-DSG1 antibody-positive individuals (18 of 19, 94.74%) was statistically significantly higher than the proportion of anti-DSG3 antibody-positive ones (10 of 19, 52.63%) (p = 0.0099).

Conclusions:
IgG deposition in the pemphigus pattern seems to be related to the presence of serum IgG antibodies against DSG1 rather than against DSG3. DSG1 may bind IgG more efficiently than DSG3 since DSG1 has a longer cytoplasmic region compared to that of DSG3

keywords:

Treatment-naïve pemphigus patients showing IgG tissue deposits have serum IgG antibodies against desmoglein 1 detected more often than those against desmoglein 3: a monocentre laboratory experience

Magdalena Jałowska 1 , Marian Dmochowski 1 , Justyna Gornowicz-Porowska 1, 2 , Monika Bowszyc-Dmochowska 3

pemphigus, immunofluorescence, desmoglein

Magdalena Jałowska

¹

,

Marian Dmochowski

¹

,

Justyna Gornowicz-Porowska

^{1, 2}

,

Monika Bowszyc-Dmochowska

³