eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Abstracting and indexing Subscription Contact Instructions for authors
SCImago Journal & Country Rank
1/2018
vol. 22
 
Share:
Share:
more
 
 
abstract:
Original paper

Uncommon reasons of the digestive tract-related paraneoplastic syndromes in children with neuroblastic tumors: three case reports

Elżbieta Czkwianianc, Beata Zalewska-Szewczyk, Józef Kobos, Anna Socha-Banasiak, Szymon Janczar, Sylwia Prymus-Kasińska, Joanna Kazanek-Zasada, Wojciech Młynarski

Contemp Oncol (Pozn) 2018; 22 (1): 42-46
Online publish date: 2018/04/03
View full text
Get citation
ENW
EndNote
BIB
JabRef, Mendeley
RIS
Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
 
Aim of the study
presentation of the uncommon paraneoplastic syndromes related to the gastrointestinal tract that may occur in children with neuroblastic tumors and their impact on the disease course.

Material and methods
Retrospective analysis of three cases of patients mainly with digestive tract-related symptoms, who were originally admitted to the gastroenterology department from 2013 to 2016 and were finally diagnosed with neuroblastic tumors.

Results
The clinical data analysis showed that the symptoms from gastrointestinal tract were dominant in analyzed subjects. The first case is a girl with weight loss, bloating and severe diarrhea, admitted to the hospital in a state of dehydration. The laboratory tests revealed severe hypokalemia. Finally, vasoactive intestinal peptide (VIP) secreting ganglioneuroblastoma was diagnosed and effective surgery was performed. The second case was also a girl who suffered from the incidents of watery diarrhea and flatulence. The tumor was detected by computerized tomography scan. The 3rd stage of ganglioneuroblastoma was diagnosed. The patient required chemotherapy, radiotherapy and surgery treatment. The third child was a boy, hospitalized due to abdominal pain, constipation and weakness. During the diagnostic process, the 4th stage of neuroblastoma was recognized. The chemotherapy, surgery, radiotherapy and immunotherapy were applied.

Conclusions
In children with common abdominal symptoms as chronic flatulence, diarrhea or severe constipation of unknown etiology, the neuroblastic tumors should be considered.

keywords:

neuroblastic tumors, VIP-secreting tumor, paraneoplastic syndrome, diarrhea, constipation

references:
Wildhaber B, Niggli F, Bergsträsser E, Stallmach T, Sacher P. Paraneoplastic syndromes in ganglioneuroblastoma: contrasting symptoms of constipation and diarrhoea. Eur J Pediatr 2003; 162: 511-3.
Schuler D, Koós R, Krauze I, Péter A. Paraneoplastic syndrome in childhood. Acta Paediatr Acad Sci Hung 1977; 18: 31-40.
Zhang WQ, Liu JF, Zhao J, Zhao SY, Xue Y. Tumor with watery diarrhoea, hypokalaemia in a 3-year-old girl. Eur J Pediatr 2009; 168: 859-62.
Parodi S, Merlo DF, Ranucci A, Miligi L, Benvenuti A, Rondelli R, Magnani C,Haupt R; SETIL Working Group. Risk of neuroblastoma, maternal characteristics and perinatal exposures: the SETIL study. Cancer Epidemiol 2014; 38: 686-94.
Bourdeaut F, de Carli E, Timsit S, et al. Neuroblastoma Committee of the Société Française des Cancers et Leucémies de l’Enfant et de l’Adolescent. VIP hypersecretion as primary or secondary syndrome in neuroblastoma: A retrospective study by the Société Française des Cancers de l’Enfant (SFCE). Pediatr Blood Cancer 2009; 52: 585-90.
Kanık A, Baran M, Çayan Ö, Eliaçık K, Özdemir T, Helvacı M, Çeçen E.
Vasoactive intestinal peptide releasing tumor which caused to chronic watery diarrhea and hypokalemia. Turk Pediatri Ars 2014; 49: 160-2.
Sintusek P, Thammarakcharoen T, Shuangshoti S, Vivatvakin B. Unremitting watery diarrhoea in early childhood period. BMJ Case Rep 2017; 2017, pii: bcr-2016-217532.
Verner JV, Morrison AB. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. Am J Med 1958; 25: 374-80.
Gesundheit B, Smith CR, Gerstle JT, Weitzman SS, Chan HS. Ataxia and secretory diarrhea: two unusual paraneoplastic syndromes occurring concurrently in the same patient with ganglioneuroblastoma. J Pediatr Hematol Oncol 2004; 26: 549-52.
Lacej SR, Gribble TJ, Kosloske AM. Favorable prognosis of vasoactive intestinal peptide-secreting ganglioneuroblastoma. Pediatr Surg Int 1989; 4: 217-9.
Pence JC, Shorter NA. The autocrine function of vasoactive intestinal peptide on human neuroblastoma cell growth and differentiation. Arch Surg 1993; 128: 591-5.
Hill JM, Mehnert J, McCune SK, Brenneman DE. Vasoactive intestinal peptide regulation of nerve growth factor in the embryonic mouse. Peptides 2002; 23: 1803-8.
Schramm A, Schulte JH, Astrahantseff K, et al. Biological effects of TrkA and TrkB receptor signaling in neuroblastoma. Cancer Lett 2005; 228: 143-53.
Brodeur GM, Minturn JE, Ho R, et al. Trk receptor expression and inhibition in neuroblastomas. Clin Cancer Res 2009; 15: 3244-50.
van den Berg MM, Benninga MA, Di Lorenzo C. Epidemiology of childhood constipation: a systematic review. Am J Gastroenterol 2006; 101: 2401-9.
Rowan-Legg A, Canadian Paediatric Society, Community Paediatrics Committee. Managing functional constipation in children. Paediatrics Child Health 2011; 16: 661-5.
Zhang YT, Feng LH, Zhang Z, Zhong XD, Chang J. Different Kinds of Paraneoplastic Syndromes in Childhood Neuroblastoma. Iran
J Pediatr 2015; 25: e266.
Wildhaber B, Niggli F, Stallmach T, Willi U, Stauffer UG, Sacher P. Intestinal pseudoobstruction as a paraneoplastic syndrome in ganglioneuroblastoma. Eur J Pediatr Surg 2002; 12: 429-31.
Drukker CA, Heij HA, Wijnaendts LC, Verbeke JI, Kaspers GJ. Paraneoplastic gastro-intestinal anti-Hu syndrome in neuroblastoma. Pediatr Blood Cancer 2009; 52: 396-8.
Pranzatelli MR, Travelstead AL, Tate ED, Allison TJ, Lee ND, Fisher J, Jasty R. Immunophenotype of blood lymphocytes in neuroblastoma-associated opsoclonus myoclonus. J Pediatr Hematol Oncol 2004; 26: 718-23.
Quick links
© 2018 Termedia Sp. z o.o. All rights reserved.
Developed by Bentus.
PayU - płatności internetowe