eISSN: 2081-2833
ISSN: 2081-0016
Medycyna Paliatywna/Palliative Medicine
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3/2017
vol. 9
 
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abstract:
Case report

Use of high doses of oxycodone-naloxone combination in the treatment of pain in patients with advanced cancer suffering from opioid bowel dysfunction (OBD) – case reports

Łukasz Pietrzyński, Mateusz Rajchel, Tatiana Pietrzyńska

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Introduction: Long-term opioid therapy for severe, chronic cancer pain is associated with a number of side effects. One of the most common is opioid bowel dysfunction (OBD). In this article, the authors present one of the options for treatment of this adverse effect by a combination of opioid analgesic formulation and opioid receptor antagonist (oxycodone and naloxone).

Case reports: The authors present reports of two patients suffering from bowel dysfunction due to long-term, high-dose, opioid chronic cancer-pain treatment. In both cases, strong opioid pharmacotherapy was changed to treatment with a combination of oxycodone and naloxone controlled-release tablets. It resulted in reduction of opioid bowel dysfunction symptoms and an increase in patient’s quality of life.

Conclusions: The presented cases illustrate the efficacy of high-dose oxycodone-naloxone combination therapy in reducing opioid bowel dysfunction while maintaining effective analgesia and good toleration of treatment.
keywords:

oxycodone, naloxone, chronic pain, constipation

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