en POLSKI
eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
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SCImago Journal & Country Rank
 
1/2022
vol. 28
 
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abstract:
Letter to the Editor

Which C-peptide assay do you use? Increasing need for describing C-peptide assay performance

Pim Dekker
1
,
Martine de Vries
1
,
Henk-Jan Aanstoot
1
,
Joost Groen
2

1.
Center for Pediatric and Adult Diabetes Care and Research, Rotterdam, The Netherlands
2.
Department of Clinical Chemistry, IJsselland Ziekenhuis, Capelle aan den IJssel, The Netherlands
Pediatr Endocrinol Diabetes Metab 2022; 28 (1): 101–103
Online publish date: 2022/03/03
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Many C-peptide assays are commercially available for research and routine use. However, not all assays yield consistent results, especially in the low concentration ranges. We searched the literature describing C-peptide measurements to assess which assays are mainly used in the diabetes research field and if they are specified. Percentages of publications on C-peptide measurements in type 1 diabetes (T1D), type 2 diabetes (T2D) and other forms of diabetes were 32%, 54% and 14%, respectively. In only 54% of the publications the used assay was specified. Information on detection limit, measurement range and variation was provided in 12%, 2% and 11% of publications, respectively. In 22% of all publications no C-peptides concentrations were mentioned. This may be a problem especially for T1D research, where measuring very low levels of C-peptide is becoming increasingly important and concordance between assays is low.
keywords:

diabetes, C-peptide, assay, detection limit


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