eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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vol. 21
Review paper

lncRNA in HNSCC: challenges and potential

Kacper Guglas, Marta Bogaczyńska, Tomasz Kolenda, Marcel Ryś, Anna Teresiak, Renata Bliźniak, Izabela Łasińska, Jacek Mackiewicz, Katarzyna Lamperska

Contemp Oncol (Pozn) 2017; 21 (4): 259-266
Online publish date: 2017/12/30
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Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. Some progress has been made in the therapy of HNSCC, however treatment remains unsatisfactory. Recent studies have shown that different types of long non-coding RNAs (lncRNAs) are dysregulated in HNSCC and correlate with tumor progression, lymph node metastasis, clinical stage and poor prognosis. lncRNAs are a class of functional RNA molecules that can not be translated into proteins but can modulate the activity of transcription factors or regulate changes in chromatin structure. The lncRNAs might have potential of biomarker in HNSCC diagnosis, prognosis, prediction and targeted treatment. In this review we describe the potential role of lncRNAs as new biomarkers and discuss their features including source of origin, extraction methods, stability, detection methods and data normalization and potential function as biomarkers in HNSCC.

HNSCC, biomarkers, lncRNA, head and neck

Zhi IX, Lamperska K, Golusinski P, Schork NJ, Luczewski L, Kolenda T et al. Gene expression analysis of head and neck squamous cell carcinoma survival and recurrence. Oncotarget 2015; 6: 547-55.
Tsang CM, Tsao SW. The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma. Virol Sin 2015; 30: 107-21.
Marur S, Forastiere AA. Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment. Mayo Clin Proc 2016; 91: 386-96.
van Oijen MG, Slootweg PJ. Oral field cancerization: carcinogen – induced independent events or micrometastatic deposits? Cancer Epidemiol Biomarkes Prev 2000; 9: 249-56.
Fuereder T. Immunotherapy for head and neck squamous cell carcinoma. Memo. 2016; 9: 66-9.
Victoria Martinez B, Dhahbi JM, et al. Circulating small non coding RNA signature in head and neck squamous cell carcinoma. Oncotarget 2015; 6: 19246-63.
Lamperska K, Kozlowski P, Kolenda T, et al. Unpredictable changes of selected miRNA in expression profile of HNSCC. Cancer Biomark 2016; 16: 55-64.
Kolenda T, Przybyła W, Teresiak A, Mackiewicz A, Lamperska K. The mystery of let-7d – a small RNA with great power. Contemp Oncol (Pozn) 2014; 18: 293-301.
Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet 2009; 10: 155-9.
Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME, Mattick JS. Genome – wide analysis of long noncoding RNA stability. Genome Res 2012; 22: 885-98.
Dinger ME, Pang KC, Mercer TR, Mattick JS. Differentiating protein coding and noncoding RNA: challenges and ambiguities. PLoS Comput Biol 2008; 4: e1000176.
Zhang W, Huang C, Gong Z, et al. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol 2013; 44: 545-54.
Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, et al.; ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 2007; 447: 799-816.
Carninci P, Kasukawa T, Katayama S, et al. The transcriptional landscape of the mammalian genome. Science 2005; 309: 1559-63.
Zhang Y, Yang L, Chen LL. Life without a tail: new formats of long noncoding RNAs. Int J Biochem Cell Biol 2014; 54: 338-49.
Furuno M, Pang KC Ninomiya N, et al. Clusters of internally primed transcripts reveal novel long noncoding RNAs. PLoS Genet 2006; 2: e37.
Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 2013; 495: 333-8.
Kun Y, Arfat Y, Li D, Zhao F, et al. Structure Prediction: New Insights into Decrypting Long Noncoding RNAs. Int J Mol Sci 2016; 17: 132.
Kong XP, Yao J, Luo W, Feng FK, Ma JT, Ren YP, Wang DL, Bu RF. The expression and functional role of a FOXC1 related mRNA-lncRNA pair in oral squamous cell carcinoma. Mol Cell Biochem 2014; 394: 177-86.
Sigova AA, Mullen AC, Molinie B, et al. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A 2013; 110: 2876-81.
Derrien T, Johnson R, Bussotti G, et al. The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res 2012; 22: 1775-89.
Cabili MN, Trapnell C, Goff L, Koziol M, Koziol M, Tazon-Vega B, Regev A, Rinn JL. Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev 2011; 25: 1915-27.
Kelley D, Rinn J. Transposable elements reveal a stem cell-specific class of long noncoding RNAs. Genome Biol 2012; 13: R107.
Hoffmann MJ, Dehn J, Droop J, et al. Truncated Isoforms of lncRNA ANRIL Are Overexpressed in Bladder Cancer, But Do Not Contribute to Repression of INK4 Tumor Suppressors. Non-Coding RNA 2015; 1: 266-84.
Huarte M, Guttman M, Feldser D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010; 142: 409-19.
Chang HY, Schmitt AM. Long Noncoding RNAs in Cancer Pathways. Cancer Cell 2016; 29: 452-63.
Yarmishyn AA, Kurochkin IV. Long noncoding RNAs: a potential novel class of cancer biomarkers. Front Genet 2015; 6: 145.
Jiang C, Li X, Zhao H, Liu H. Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis. Mol Cancer 2016; 15: 62.
Ahlawat P, Rawat S, Kakria A, Pal M, Chauhan D, Tandon S, Jain S. Tumour volumes: Predictors of early treatment response in locally advanced head and neck cancers treated with definitive chemoradiation. Rep Pract Oncol Radiother 2016; 21: 419-26.
González Ferreira JA, Jaén Olasolo J, Azinovic I, Jeremic B. Effect of radiotherapy delay in overall treatment time on local control and survival in head and neck cancer: Review of the literature. Rep Pract Oncol Radiother 2015; 20: 328-39.
Eissa S, Matboli M, Essawy NO, Shehta M, Kotb YM. Rapid detection of urinary long non-coding RNA urothelial carcinoma associated one using a PCR-free nanoparticle-based assay. Biomarkers 2015; 20: 212-7.
Zhang H, Zhao L, Wang YX, Xi M, Liu SL, Luo LL. Long non-coding RNA HOTTIP is correlated with progression and prognosis in tongue squamous cell carcinoma. Tumour Biol 2015; 36: 8805-9.
Kolenda T, Teresiak A, Kapałczyńska M, Przybyła W, Zajączkowska M, Bliźniak R, Masternak MM, Golusinski P, Golusinski W. Let-7d and miR-18a as biomarkers of head and neck cancers. Lett Oncol Sci 2015; 12: 37-47.
Gezer U, Özgür E, Cetinkaya M, Isin M, Dalay N. Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes. Cell Biol Int 2014; 38: 1076-9.
Fayda M, Isin M, Tambas M, et al. Do circulating long non-coding RNAs (lncRNAs) (LincRNA-p21, GAS 5, HOTAIR) predict the treatment response in patients with head and neck cancer treated with chemoradiotherapy? Tumour Biol 2016; 37: 3969-78.
Tang H, Wu Z, Zhang J, Su B. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis. Mol Med Rep 2013; 7: 761-6.
Zhou X, Yin C, Dang Y, Ye F, Zhang G. Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer. Sci Rep 2015; 5: 11516.
Kraus TF, Greiner A, Guibourt V, Lisec K, Kretzschmar HA. Identification of Stably Expressed lncRNAs as Valid Endogenous Controls for Profiling of Human Glioma. J Cancer 2015; 6: 111-9.
Kraus TF, Greiner A, Guibourt V, Kretzschmar HA. Long non-coding RNA normalisers in human brain tissue. J Neural Transm (Vienna) 2015; 122: 1045-54.
Kokkat TJ, Patel MS, McGarvey D, LiVolsi VA, Baloch ZW. Archived formalin-fixed paraffin-embedded (FFPE) blocks: A valuable underexploited resource for extraction of DNA, RNA, and protein. Biopreserv Biobank 2013; 11: 101-6.
Kong H, Zhu M, Cui F, Wang S, Gao X, Lu S, Wu Y, Zhu H. Quantitative assessment of short amplicons in FFPE-derived long-chain RNA. Sci Rep 2014; 4: 7246.
Shi T, Gao G, Cao Y. Long Noncoding RNAs as Novel Biomarkers Have a Promising Future in Cancer Diagnostics. Dis Markers 2016; 2016: 9085195.
Qi P, Zhou XY, Du X. Circulating long non-coding RNAs in cancer: current status and future perspectives. Mol Cancer 2016; 15: 39.
Pritchard CC, Kroh E, Wood B, Arroyo JD, Dougherty KJ, Miyaji MM, Tait JF. Tewari M. Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev Res (Phila) 2012; 5: 492-7.
Qin J, Williams TL, Fernando MR. A novel blood collection device stabilizes cell-free RNA in blood during sample shipping and storage. BMC Res Notes 2013; 6: 380.
Feng Y, Hu X, Zhang Y, Zhang D, Li C, Zhang L. Methods for the Study of Long Noncoding RNA in Cancer Cell Signaling Methods. Methods Mol Biol 2014; 1165: 115-43.
Wojdacz TK, Dobrovic A, Algar EM. Rapid detection of methylation change at H19 in human imprinting disorders using methylation-sensitive high-resolution melting. Hum Mutat 2008; 29: 1255-60.
Dodd DW, Gagnon KT, Corey DR. Digital quantitation of potential therapeutic target RNAs. Nucleic Acid Ther 2013; 23: 188-94.
Oleksiewicz U, Tomczak K, Woropaj J, Markowska M, Stępniak P, Shah PK. Computational characterisation of cancer molecular profiles derived using next generation sequencing. Contemp Oncol (Pozn) 2015; 19 (1A): A78-A91.
Tomczak K, Czerwińska P, Wiznerowicz M. The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol (Pozn) 2015; 19 (1A): A68-77.
Gee HE, Buffa FM, Camps C, The small-nucleolar RNAs commonly used for microRNA normalisation correlate with tumour pathology and prognosis. Br J Cancer 2011; 104: 1168-77.
Desai S, Ding M, Wang B, Lu Z, Zhao Q, Shaw K, et al. Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers. Oncotarget 2014; 5: 8202-10.
Pang KC, Frith MC, Mattick JS. Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function. Trends Genet 2006; 22: 1-5.
Hüttenhofer A, Schattner P, Polacek N. Non-coding RNAs: hope or hype? Trends Genet 2005; 21: 289-97.
Fang Z, Zhang S, Wang Y, et al. Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins. BMC Cancer 2016; 16: 706.
Dong L, Qi P, Xu MD, et al. Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls. Int J Cancer 2015; 137: 1128-35.
Reddy MA, Chen Z, Park JT, et al. Regulation of inflammatory phenotype in macrophages by a diabetes-induced long noncoding RNA. Diabetes 2014; 63: 4249-61.
Trimarchi T, Bilal E, Ntziachristos P, Fabbri G, Dalla-Favera R, Tsirigos A, Aifantis I. Genome-wide mapping and characterization of Notch-regulated long noncoding RNAs in acute leukemia. Cell 2014; 158: 593-606.
Huarte M. The emerging role of lncRNAs in cancer. Nature Med 2015; 21: 1253-61.
Wang WT, Sun YM, Huang W, He B, Zhao YN, Chen YQ. Genome-wide long non-coding RNA analysis identified circulating LncRNAs as novel non-invasive diagnostic biomarkers for gynecological disease. Sci Rep 2016; 6: 23343.
Bussemakers MJ, van Bokhoven A, Verhaegh GW, et al. DD3: a new prostate-specific gene, highly overexpressed in prostate cancer. Cancer Res 1999; 59: 5975-9.
Zou AE, Ku J, Honda TK, et al. Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA 2015; 21: 1122-34.
Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, et al. The non-coding landscape of head and neck squamous cell carcinoma. Oncotarget 2016; 7: 51211-22.
Nohata N, Abba MC, Gutkind JS. Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection. Oral Oncol 2016; 59: 58-66.
Yang QQ, Deng YF. Genome-wide analysis of long non-coding RNA in primary nasopharyngeal carcinoma by microarray. Histopathology 2015; 66: 1022-30.
Zhang S, Tian L, Ma P, Sun Q, Zhang K, Liu H, et al. Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma. Arch Oral Biol 2015; 60: 1581-7.
Kolenda T, Guglas K, Ryś M, Bogaczyńska M, Teresiak A, Bliźniak R, et al. Biological role of lncRNA in head and neck cancers. Rep Pract Oncol Radiother 2017; 22: 378-388..
Sun Q, Liu H, Li L, Zhang S, Liu K, Liu Y, Yang C. Long noncoding RNA-LET, which is repressed by EZH2, inhibits cell proliferation and induces apoptosis of nasopharyngeal carcinoma cell. Med Oncol 2015; 32: 226.
Zhang W, Wang L, Zheng F, et al. Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value. BioMed Res Intl 2015; 2015: 618924.
Ren S, Li G, Liu C, et al. Next generation deep sequencing identified a novel lncRNA n375709 associated with paclitaxel resistance in nasopharyngeal carcinoma. Oncol Rep 2016; 36: 1861-7.
Chen H, Xin Y, Zhou L, Huang JM, Tao L, Cheng L, Tian J. Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma. Med Oncol 2014; 31: 246.
Li L, Gu M, You B, Shi S, Shan Y, Bao L, You Y. Long non-coding RNA ROR promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma. Cancer Sci 2016; 107: 1215-22.
Li G, Liu Y, Liu C, et al. Genome – wide analyses of long noncoding RNA expression profiles correlated with radioresistance in nasopharyngeal carcinoma via nest – generation deep sequencing. BMC Cancer 2016; 16: 719.
Zhou J, Li M, Yu W, et al. AB209630, a long non-coding RNA decreased expression in hypopharyngeal squamous cell carcinoma, influences proliferation, invasion, metastasis and survival. Oncotarget 2016; 7 (12): 14628-38.
Zhang B, Wang D, Wu J, et al. Expression profiling and functional prediction of long noncoding RNAs in nasopharyngeal nonkeratinizing carcinoma. Discov Med 2016; 21: 239-50.
Wang P, Wu T, Zhou H, et al. Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway. J Exp Clin Cancer Res 2016; 35: 22.
Gonzalez-Ramirez I, Soto-Reyes E, Sanchez-Perez Y, Herrera LA, Garcia-Cuellar C. Histones and long non-coding RNAs: The new insight of epigenetic deregulation involved in oral cancer. Oral Oncol 2014; 50: 691-5.
Wu Y, Zhang L, Wang Y, et al. Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int J Oncol 2015; 46: 2586-94.
Wang J, Zhou Y, Lu J, Sun Y, Xiao H, Liu M, Tian L. Combined detection of serum exosomal miR-21 and HOTAIR as diagnostic and prognostic biomarkers for laryngeal squamous cell carcinoma. Med Oncol 2014; 31: 148.
Nie Y, Liu X, Qu S, Song E, Zou H, Gong C. Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival. Cancer Sci 2013; 104: 458-64.
Fu WM, Lu YF, Hu BG, et al. Long noncoding RNA Hot air mediated angiogenesis in nasopharyngeal carcinoma by direct and indirect signalling pathways. Oncotarget 2016; 7: 4712-23.
Fang Z, Wu L, Wang L, Yang Y, Meng Y, Yang H. Increased expression of the long non-coding RNA UCA1 in tongue squamous cell carcinomas: a possible correlation with cancer metastasis. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117: 89-95.
Shen Z, Li Q, Deng H, Lu D, Song H, Guo J. Long non-coding rna profiling in laryngeal squamous cell carcinoma and its clinical significance: potential biomarkers for LSCC. PLoS One 2014; 9: e108237.
Song P, Ye LF, Zhang C, Peng T, Zhou XH. Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p. Gene 2016; 592: 8-14.
Jia LF, Wei SB, Gan YH, Gou YK, Gong K, Mitchelson K, Cheng J, Yu GY. Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma. Int J Cancer 2014; 135: 2282-93.
Liang J, Liang L, Ouyang K, Li Z, Yi X. MALAT1 induces tongue cancer cells’ EMT and inhibits apoptosis through Wnt/-catenin signaling pathway. J Oral Pathol Med 2016; 46: 98-105.
Wu T, Qu L, He G, et al. Regulation of laryngeal squamous cell cancer progression by the lncRNA H19/miR-148a-3p/DNMT1 axis. Oncotarget 2016; 7: 11553-66.
Huang W, Cui X, Chen J, Feng Y, Song E, Li J, Liu Y. Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial – mesenchymal transition. Oncotarget 2016; 7: 62520-32.
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