eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2015
vol. 40
 
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abstract:
Clinical immunology

Aspergillus galactomannan detection in comparison to a real-time PCR assay in serum samples from a high-risk group of patients

Ewa Swoboda-Kopeć
,
Marlena Gołaś
,
Katarzyna Piskorska
,
Maria Dąbkowska
,
Irena Niecwietajewa
,
Leszek Pączek
,
Magdalena Sikora

(Cent Eur J Immunol 2015; 40 (4): 454-460)
Online publish date: 2016/01/15
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Invasive aspergillosis (IA) is a severe infection with a 70% mortality rate. Aspergillus fumigatus is responsible for over 90% of those infections.

The diagnosis of invasive aspergillosis is based on clinical sample culture and detection of fungal hyphae in histopathological examination. Additional tests may include the detection of the galactomannan antigen and of fungal genetic material in serum and bronchoalveolar washings. The present study was to assess the use of these two rapid tests in the diagnosis of invasive aspergillosis: serological one – to detect the galactomannan antigen (ELISA assay), and real-time PCR, and to establish a possible correlation between these two methods.

keywords:

Aspergillus, real-time PCR, galactomannan, aspergillosis, MycassayTM

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