eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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1/2019
vol. 23
 
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abstract:
Original paper

18F-fluoro-ethyl-tyrosine (18F-FET) PET/CT as a potential new diagnostic tool in multiple myeloma: a preliminary study

Jarosław Czyż
1
,
Bogdan Małkowski
2
,
Artur Jurczyszyn
3
,
Norbert Grząśko
4
,
Rita Łopatto
2
,
Monika Olejniczak
5
,
Adriana Czyż
1
,
Anna Jachalska
6

1.
Department of Haematology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland
2.
Department of Nuclear Medicine, Professor Franciszek Lukaszczyk Oncology Centre in Bydgoszcz, Bydgoszcz, Poland
3.
Department of Haematology, Jagiellonian University Medical College, Krakow, Poland
4.
Department of Haematology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland
5.
Department of Oncology, Professor Franciszek Lukaszczyk Oncology Centre in Bydgoszcz, Bydgoszcz, Poland
6.
Department of Haematology, Dr. Jan Biziel University Hospital No. 2 in Bydgoszcz, Bydgoszcz, Poland
Contemp Oncol (Pozn) 2019; 23 (1): 23-31
DOI: https://doi.org/10.5114/wo.2019.83342
Online publish date: 2019/03/04
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Aim of the study
The aim of this study was to analyse the diagnostic accuracy of “18F-fluoro-ethyl-tyrosine (18F-FET) PET/CT tracer in multiple mye­loma.

Material and methods
The analysed group included: patients with newly diagnosed active myeloma (eight patients); in very good partial remission or complete remission (VGPR or CR) after treatment (nine patients); and with active disease after relapse (15 patients).

Results
In patients with newly diagnosed myeloma, 64 lesions were found using CT and 83 lesions using 18F-FET. In six patients, the number of lesions using CT and 18F-FET was the same, and two had more lesions with the 18F-FET than with the CT. Patients in VGPR or CR had no FET-positive lesions. Fourteen out of 15 patients with active relapsed myeloma had 47 FET-positive lesions, CT assessment of the same group showed 282 lesions. In one patient with relapse soft tissue mass was found with 18F-FET but not with CT.

Conclusions
18F-FET can be a promising alternative to 18F-FDG PET/CT for myeloma-related bone disease diagnosis.

keywords:

multiple myeloma, 18F-FET, 18F-FDG PET/CT
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