Biology of Sport
eISSN: 2083-1862
ISSN: 0860-021X
Biology of Sport
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vol. 37
Original paper

Acute response of biochemical bone turnover markers and the associated ground reaction forces to high-impact exercise in postmenopausal women

Rizky S Prawiradilaga
1, 2
Anders O Madsen
Niklas R Jørgensen
3, 4
Eva W Helge

Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark Nørre Allé 51, 2200 Copenhagen N, Denmark
Faculty of Medicine, Universitas Islam Bandung, Indonesia Tamansari No.20, Bandung 40116, Jawa Barat, Indonesia
Department of Clinical Biochemistry, Rigshospitalet Glostrup, Denmark Valdemar Hansens Vej 13, 2600 Glostrup, Denmark
OPEN, Odense Patient data Explorative Network, Odense University Hospital/Institute of Clinical Research, University of Southern Denmark, Odense, Denmark J.B. Winsløws Vej 4, 5000 Odense C, Denmark
Biol Sport. 2020;37(1):41–48.
Online publish date: 2020/02/07
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The aim of the study was to examine the acute response of biochemical bone turnover markers (BTM) to high-impact jumping exercise, and to quantify the ground reaction forces (GRF) achieved during each jumping exercise, in postmenopausal women. In a randomized controlled cross-over study over three days, 29 postmenopausal women (age (mean±SD): 60.0±5.6 years) were randomly assigned to 6 x 10 repetitions of three different jumps: countermovement jump (CMJ), drop jump (DJ), diagonal drop jump (DDJ). A fourth day without jumping served as a control (CON). Blood samples were collected before (PRE), after (POST), and 2 hours after (2Hr) exercise. Bone turnover was evaluated by bone formation markers (procollagen type-1 aminoterminal propeptide (P1NP) and osteocalcin (OC)) and the bone resorption marker C-terminal telopeptide of type-1 collagen (CTX). Peak anteroposterior (Fx), mediolateral (Fy), and vertical (Fz) GRF were measured using a force platform. From PRE to POST, P1NP increased (p<0.01) by 7.7±1.8%, 9.4±1.3%, and 10.6±1.6% for CMJ, DJ, and DDJ, which were higher (p<0.01) than CON. OC increased (p<0.05) by 5.5±1.8% for DJ, which was higher (p<0.05) than CON. CTX was not significantly changed at POST. There were no significant differences in BTM Δ-values between the jumps at any time point. For the CMJ, the combined three-axis peak GRF was positively associated with the PRE to POST Δ-change in P1NP (r=0.71, p<0.05). The acute, jumping-induced increase in P1NP and OC without any rise in CTX may indicate increased bone formation. Moreover, the study shows a dose-response relationship between GRF and the acute P1NP response after countermovement jumps.

Bone formation, Bone resorption, Jumping, Osteogenic exercise, Weight-bearing exercise, Odd-impact

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