eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2019
vol. 44
 
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abstract:
Experimental immunology

Anti-inflammatory activity of elicited soybean (Glycine max) extract on Balb/C mice (Mus musculus) with high-fat and -fructose diet

Farida D. Nur’aini
,
Sri Rahayu
,
Muhaimin Rifa’i

(Centr Eur J Immunol 2019; 44 (1): 7-14)
Online publish date: 2019/04/15
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Obesity causes adipocyte hypertrophy, which leads to cell death. Consequently, macrophages and lymphocytes infiltrate into the adipose tissue and elevate pro-inflammatory cytokine production through TLR activation. This study aimed to determine the efficacy of soybean extract, which was elicited by Saccharomyces cerevisiae and light, as an anti-inflammatory agent in mice with a high-fat and -fructose diet (HFFD). The elicited soybean extract (ESE) was administered orally to mice for four weeks after being given an HFFD for 20 weeks. Three different doses were used: (1) low-dose (78 mg/kg BW); (2) normal dose (104 mg/kg BW); and (3) high dose (130 mg/kg BW). HFFD mice model treated with simvastatin 2.8 mg/kg BW considered as drug control. After 24 weeks, the lymphocytes were isolated and the relative number of CD4+TLR3+ T, CD4+TLR4+ T, CD4+TNF-α+ T, and CD4+IFN-γ+ T cells were analysed using flow cytometry. The results showed that the HFFD mouse model had an increased number of CD4+TLR3+ T, CD4+TLR4+ T, CD4+TNF-α+ T, and CD4+IFN-γ+ T cells. ESE administration decreased the relative number of CD4+TLR3+ T, CD4+TLR4+ T, CD4+TNF-α+ T, and CD4+IFN-γ+ T cells. The normal dose of ESE is the most effective dose in suppressing inflammation compared to positive controls. ESE 104 mg/kg BW can be considered as an alternative herbal medicine that may suppress inflammation in HFFD mice.
keywords:

high fat-fructose diet, anti-inflammatory, elicited soybean extract

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