eISSN: 2450-4459
ISSN: 2450-3517
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1/2019
vol. 5
 
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abstract:
Review paper

Application of butyric acid preparations in clinical practice

Barbara Skrzydło-Radomańska

Online publish date: 2019/03/20
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Butyric acid is a natural substance, one of the three short-fatty acids (SCFA), physiologically produced by the colonic microbial fermentation of digestible carbohydrates. Butyric acid is a basic source of energy for intestinal epithelial cells and an important factor stimulating their growth and differentiation. The role of butyrate as a trophic agent, its effect on the proliferation and apoptosis, and its cytoprotective and anti-inflammatory properties are widely recognised. Butyric acid directly inhibits the enzymatic activity of histone deacetylase (HDAC), suppresses cell-cycle, stimulates cell differentiation, exerts immunomodulatory and anti-inflammatory effects, regulates intestinal barrier, reduces oxidative stress, and modulates visceral sensitivity and motility. Beneficial effects of butyric acid were observed in inflammatory bowel diseases, radiation and post-chemotherapy colitis, pouchitis, diverticular disease, infectious diarrhoea, and functional intestinal diseases. The innovative technology of preparing microparticles in a lipid matrix has enabled efficacious administration of this natural and safe substance.
keywords:

butyric acid, short-chain fatty acids, functional bowel diseases, inflammatory bowel diseases

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