eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
2/2021
vol. 16
 
Share:
Share:
abstract:
Original paper

Association between serum 25-hydroxy vitamin D level and gastric adenocarcinoma – a cross sectional study

Arulraj Kevin
1
,
Amaranathan Anandhi
1
,
Subitha Lakshminarayanan
1
,
Sathasivam Sureshkumar
1
,
Sadishkumar Kamalanathan
1

1.
Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
Gastroenterology Rev 2021; 16 (2): 155–160
Online publish date: 2020/11/05
View full text Get citation
 
PlumX metrics:
Introduction
Vitamin D is found to have anti-cancer properties. Although the preventive role of vitamin D in cancer is proven, its role in gastric cancer is equivocal.

Aim
To evaluate vitamin D deficiency in patients with gastric adenocarcinoma and its relationship with the disease characteristics.

Material and methods
This single-centre, prospective, cross sectional study was carried out from February 2017 to December 2018. Serum 25-hydroxy vitamin D levels of 94 patients with gastric adenocarcinoma and 94 age- and sex-matched healthy controls were estimated. Among cases, vitamin D levels and disease characteristics such as TNM stage, tumour grade, clinical stage and patient demographics were analysed.

Results
The vitamin D levels among cases (13.83 ±5.97 ng/ml) were significantly lower (p < 0.0001) than the control group (29.15 ±4.13 ng/ml). Vitamin D deficiency was found in 88% of cases and in 3% of controls. Among cases, age, T stage and clinical stage had a significant inverse relationship with vitamin D levels. Cases with distant metastasis and cases with pain had significantly lower levels of vitamin D compared to the cases without distant metastasis and without pain respectively. Other study parameters did not have a significant relationship with vitamin D.

Conclusions
Vitamin D deficiency is associated with occurrence of gastric adenocarcinoma and correlates with the disease severity. However, to assign a causal relationship and to study the beneficial effect of vitamin D in gastric cancer, further research is needed.

keywords:

gastric carcinoma, vitamin D, vitamin D deficiency

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.