eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2013
vol. 38
 
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abstract:

Association study between polymorphism of interleukin 12B 1188A/C and hepatitis B virus infection in a Chinese Han population

Zusen Wang
,
Congcong Yin
,
Jingyu Cao
,
Xue Qin Wang
,
Wei Ren
,
Feilong Huang
,
Chengyu Shi
,
Dawei Sun
,
Liqun Wu
,
Shiguo Liu

(Centr Eur J Immunol 2013; 38 (4): 470-474)
DOI: https://doi.org/10.5114/ceji.2013.39763
Online publish date: 2013/12/30
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Background: Several studies demonstrated that the genetic factor contributes a lot to the etiology of hepatitis B virus (HBV) infection. Interleukin 12 (IL-12) plays an important role in the immune response to many viruses. As a functional SNP locus, IL-12B 1188A/C polymorphism (rs3212227) showed an effect on IL-12 production, which may indicate that this polymorphism may influence immune response to HBV during a natural infection.

Objective: To investigate whether the IL-12B 1188A/C polymorphism is associated with a risk of HBV infection in the Chinese Han population.

Material and methods: Our study was performed on 594 HBV-infected persons and 535 controls. Genotyping procedures for identifying the rs3212227 polymorphism were effected by the polymerase chain reaction – restriction fragment length polymorphism (PCR-RFLP) method. Amplified ribosomal DNA restriction analysis was used to validate genotype results. 2 test was used to analyze association analysis.

Results: There was no statistically significant association between the IL-12B 1188 A/C polymorphism in HBV-infected persons and controls (for genotypes, 2 = 1.976, p = 0.372, df = 2, and for alleles, p = 0.623, OR = 0.959, 95% CI: 0.811-1.134).

Conclusions: Our results indicated that the IL-12B1188 A/C polymorphism was not associated with the development of HBV infection in the Chinese Han population.
keywords:

IL-12B 1188A/C, HBV, association study

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