Biology of Sport
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Original paper

Associations of physical activity domains and delayed biological aging: assessing heterogeneity and interaction of effects

Yongyu Huang
1
,
Yang Wang
1
,
Yanwei You
2
,
Ming Ding
3
,
Zuosheng Lu
1
,
Qing Wang
4, 5

  1. School of Physical Education and Sports Science, South China Normal University, Guangzhou, China
  2. Division of Sports Science & Physical Education, Tsinghua University, Beijing 100084, China
  3. Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166 China
  4. Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China
  5. State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China
Biol Sport. 2026;43:847–873
DOI: https://doi.org/10.5114/biolsport.2026.158670
Online publish date: 2026/02/06
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1. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013; 153(6):1194–1217. doi: 10.1016/j.cell.2013.05.039.
2. Ferrucci L, Gonzalez-Freire M, Fabbri E, et al. Measuring biological aging in humans: A quest. Aging Cell. 2020; 19(2):e13080. doi: 10.1111/acel.13080.
3. Kothari M, Belsky DW. Unite to predict. Elife. 2021; 10:e66223. Published 2021 Feb 12. doi: 10.7554/eLife .66223.
4. Belsky DW, Moffitt TE, Cohen AA, et al. Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?. Am J Epidemiol. 2018; 187(6):1220–1230. doi: 10.1093/aje /kwx346.
5. Li X, Ploner A, Wang Y, et al. Longitudinal trajectories, correlations and mortality associations of nine biological ages across 20-years follow-up. Elife. 2020; 9:e51507. Published 2020 Feb 11. doi: 10.7554/eLife.51507.
6. Yoo J, Kim Y, Cho ER, Jee SH. Biological age as a useful index to predict seventeen-year survival and mortality in Koreans. BMC Geriatr. 2017; 17(1):7. Published 2017 Jan 5. doi: 10.1186 /s12877-016-0407-y.
7. Thomas A, Belsky DW, Gu Y. Healthy Lifestyle Behaviors and Biological Aging in the U.S. National Health and Nutrition Examination Surveys 1999–2018. J Gerontol A Biol Sci Med Sci. 2023; 78(9):1535–1542. doi: 10.1093 /gerona/glad082.
8. Mhamdi S, Chamari K, BaHammam AS, Alkeridy WA, Aldeeri AA, Ben Saad H. Aging reimagined: Bridging clinical modulation and scientific breakthroughs. Biol Sport. 2026; 43(1):617–630. doi: 10.5114/biolsport.2026.156224.
9. Jin S, Li C, Cao X, Chen C, Ye Z, Liu Z. Association of lifestyle with mortality and the mediating role of aging among older adults in China. Arch Gerontol Geriatr. 2022; 98:104559. doi: 10.1016 /j.archger.2021.104559.
10. Yang Z, Pu F, Cao X, et al. Does healthy lifestyle attenuate the detrimental effects of urinary polycyclic aromatic hydrocarbons on phenotypic aging? An analysis from NHANES 2001–2010. Ecotoxicol Environ Saf. 2022; 237:113542. doi: 10.1016 /j.ecoenv.2022.113542.
11. Bull FC, Al-Ansari SS, Biddle S, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020; 54(24):1451–1462. doi: 10.1136/bjsports-2020-102955.
12. Lee IM, Shiroma EJ, Lobelo F, et al. Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet. 2012; 380(9838):219–229. doi: 10.1016/ S0140-6736(12)61031-9.
13. O’Donovan G, Petermann-Rocha F, Ferrari G, et al. Associations of the ‘weekend warrior’ physical activity pattern with mild dementia: findings from the Mexico City Prospective Study. Br J Sports Med. 2025; 59(5):325–332. Published 2025 Feb 20. doi: 10.1136 /bjsports-2024-108460.
14. Shi H, Hu FB, Huang T, et al. Sedentary Behaviors, Light-Intensity Physical Activity, and Healthy Aging. JAMA Netw Open. 2024; 7(6):e2416300. Published 2024 Jun 3. doi: 10.1001 /jamanetworkopen.2024.16300.
15. Holtermann A, Schnohr P, Nordestgaard BG, Marott JL. The physical activity paradox in cardiovascular disease and all-cause mortality: the contemporary Copenhagen General Population Study with 104 046 adults. Eur Heart J. 2021; 42(15):1499–1511. doi: 10.1093 /eurheartj/ehab087.
16. Nagata M, Komaki S, Nishida Y, et al. Influence of physical activity on the epigenetic clock: evidence from a Japanese cross-sectional study. Clin Epigenetics. 2024; 16(1):142. Published 2024 Oct 15. doi: 10.1186 /s13148-024-01756-1.
17. Lu TY, Wang J, Jiang CQ, et al. Active longevity and aging: dissecting the impacts of physical and sedentary behaviors on longevity and age acceleration. Geroscience. 2025; 47(3):3525–3538. doi: 10.1007 /s11357-024-01329-3.
18. Wu D, Huang P, Geng X, et al. Dose-response relationship between leisure-time physical activity patterns and phenotypic age acceleration in American adults: A cross-sectional analysis. J Exerc Sci Fit. 2024; 22(4):445–455. doi: 10.1016/j.jesf.2024.09.005.
19. Armstrong T, Bull F. Development of the World Health Organization Global Physical Activity Questionnaire (GPAQ). J Public Health. 2006; 14(2):66–70. doi: 10.1007/s10389-006-0024-x.
20. Klemera P, Doubal S. A new approach to the concept and computation of biological age. Mech Ageing Dev. 2006; 127(3):240–248. doi: 10.1016 /j.mad.2005.10.004.
21. Levine ME. Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?. J Gerontol A Biol Sci Med Sci. 2013; 68(6):667–674. doi: 10.1093/gerona/gls233.
22. Arbeev KG, Ukraintseva SV, Bagley O, et al. “Physiological Dysregulation” as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease. J Gerontol A Biol Sci Med Sci. 2019; 74(4):462–468. doi: 10.1093/gerona /gly136.
23. Cohen AA, Milot E, Yong J, et al. A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mech Ageing Dev. 2013; 134(3–4):110–117. doi: 10.1016 /j.mad.2013.01.004.
24. Li Q, Wang S, Milot E, et al. Homeostatic dysregulation proceeds in parallel in multiple physiological systems. Aging Cell. 2015; 14(6):1103–1112. doi: 10.1111/acel.12402.
25. Gao X, Geng T, Jiang M, et al. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants. Nat Commun. 2023; 14(1):2277. Published 2023 Apr 20. doi: 10.1038/s41467-023-38013-7.
26. Chen L, Wu B, Mo L, et al. Associations between biological ageing and the risk of, genetic susceptibility to, and life expectancy associated with rheumatoid arthritis: a secondary analysis of two observational studies. Lancet Healthy Longev. 2024; 5(1):e45–e55. doi: 10 .1016/S2666-7568(23)00220-9.
27. Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: A cohort study. PLoS Med. 2018; 15(12):e1002718. Published 2018 Dec 31. doi: 10.1371/journal .pmed.1002718.
28. Graf GH, Crowe CL, Kothari M, et al. Testing Black-White Disparities in Biological Aging Among Older Adults in the United States: Analysis of DNA-Methylation and Blood-Chemistry Methods. Am J Epidemiol. 2022; 191(4):613–625. doi: 10.1093/aje /kwab281.
29. Mitnitski A, Howlett SE, Rockwood K. Heterogeneity of Human Aging and Its Assessment. J Gerontol A Biol Sci Med Sci. 2017; 72(7):877–884. doi: 10.1093/gerona/glw089.
30. Jia L, Zhang W, Chen X. Common methods of biological age estimation. Clin Interv Aging. 2017; 12:759–772. Published 2017 May 11. doi: 10.2147 /CIA.S134921.
31. Levine ME, Lu AT, Quach A, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018; 10(4):573–591. doi: 10.18632 /aging.101414.
32. Prince SA, Rasmussen CL, Biswas A, et al. The effect of leisure time physical activity and sedentary behaviour on the health of workers with different occupational physical activity demands: a systematic review. Int J Behav Nutr Phys Act. 2021; 18(1):100. Published 2021 Jul 20. doi: 10.1186/s12966 -021-01166-z.
33. Suutari-Jääskö A, Parkkila K, Perkiömäki J, Huikuri H, Kesäniemi YA, Ukkola OH. Leisure time and occupational physical activity, overall and cardiovascular mortality: a 24-year follow-up in the OPERA study. Ann Med. 2023; 55(2):2245429. doi: 10.1080 /07853890.2023.2245429.
34. Zhu J, Yang Y, Zeng Y, et al. The Association of Physical Activity Behaviors and Patterns With Aging Acceleration: Evidence From the UK Biobank. J Gerontol A Biol Sci Med Sci. 2023; 78(5):753–761. doi: 10.1093/gerona /glad064.
35. Harvey SB, Modini M, Joyce S, et al. Can work make you mentally ill? A systematic meta-review of work-related risk factors for common mental health problems. Occup Environ Med. 2017; 74(4):301–310. doi: 10.1136/oemed-2016-104015.
36. Poganik JR, Zhang B, Baht GS, et al. Biological age is increased by stress and restored upon recovery. Cell Metab. 2023; 35(5):807–820.e5. doi: 10.1016/j.cmet.2023.03.015.
37. Virtanen M, Ferrie JE, Gimeno D, et al. Long working hours and sleep disturbances: the Whitehall II prospective cohort study. Sleep. 2009; 32(6):737–745. doi: 10 .1093/sleep/32.6.737.
38. Virtanen M, Magnusson Hansson L, Goldberg M, et al. Long working hours, anthropometry, lung function, blood pressure and blood-based biomarkers: cross-sectional findings from the CONSTANCES study. J Epidemiol Community Health. 2019; 73(2):130–135. doi: 10.1136 /jech-2018-210943.
39. Holtermann A, Krause N, van der Beek AJ, Straker L. The physical activity paradox: six reasons why occupational physical activity (OPA) does not confer the cardiovascular health benefits that leisure time physical activity does. Br J Sports Med. 2018; 52(3):149–150. doi: 10.1136/bjsports-2017-097965.
40. Stringhini S, Carmeli C, Jokela M, et al. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1.7 million men and women. Lancet. 2017; 389(10075):1229–1237. doi: 10.1016 /S0140-6736(16)32380-7.
41. Puterman E, Weiss J, Lin J, et al. Aerobic exercise lengthens telomeres and reduces stress in family caregivers: A randomized controlled trial – Curt Richter Award Paper 2018. Psychoneuroendocrinology. 2018; 98:245–252. doi: 10.1016 /j.psyneuen.2018.08.002.
42. Schellnegger M, Lin AC, Hammer N, Kamolz LP. Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review. Sports Med Open. 2022; 8(1):111. Published 2022 Sep 4. doi: 10.1186/s40798-022-00503-1.
43. Denham J, O’Brien BJ, Charchar FJ. Telomere Length Maintenance and Cardio-Metabolic Disease Prevention Through Exercise Training. Sports Med. 2016; 46(9):1213–1237. doi: 10.1007/s40279-016-0482-4.
44. Arsenis NC, You T, Ogawa EF, Tinsley GM, Zuo L. Physical activity and telomere length: Impact of aging and potential mechanisms of action. Oncotarget. 2017; 8(27):45008–45019. doi: 10.18632 /oncotarget.16726.
45. Denham J, Sellami M. Exercise training increases telomerase reverse transcriptase gene expression and telomerase activity: A systematic review and meta-analysis. Ageing Res Rev. 2021; 70:101411. doi: 10.1016 /j.arr.2021.101411.
46. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA. The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol. 2011; 11(9):607–615. Published 2011 Aug 5. doi: 10.1038 /nri3041.
47. Slavin MB, Khemraj P, Hood DA. Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle. Biomed J. 2024; 47(1):100636. doi: 10.1016/j.bj.2023.100636.
48. Dadkhah M, Saadat M, Ghorbanpour AM, Moradikor N. Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy. Brain Behav Immun Integr. 2023; 3:100017. doi: 10.1016/j.bbii.2023.100017.
49. Piepmeier AT, Etnier JL. Brain-derived neurotrophic factor (BDNF) as a potential mechanism of the effects of acute exercise on cognitive performance. J Sport Health Sci. 2015; 4(1):14–23. doi: 10.1016/j.jshs.2014.11.001.
50. Hansmann R, Hug SM, Seeland K. Restoration and stress relief through physical activities in forests and parks. Urban For Urban Green. 2007; 6(4):213–225. doi: 10.1016 /j.ufug.2007.08.004.
51. Liu C, Hua L, Xin Z. Synergistic impact of 25-hydroxyvitamin D concentrations and physical activity on delaying aging. Redox Biol. 2024; 73:103188. doi: 10.1016 /j.redox.2024.103188.
52. Wang X, Yan X, Zhang J, et al. Associations of healthy eating patterns with biological aging: national health and nutrition examination survey (NHANES) 1999–2018. Nutr J. 2024; 23(1):112. Published 2024 Sep 28. doi: 10.1186 /s12937-024-01017-0.
53. Jia J, Wen CP, Tu H, et al. Lifestyles modify the biological aging process: evidence from multiple cohorts. Am J Epidemiol. 2025; 194(11):3229–3237. doi: 10.1093/aje /kwaf138.
54. Jain P, Binder AM, Chen B, et al. Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women. JAMA Netw Open. 2022; 5(7):e2223285. Published 2022 Jul 1. doi: 10.1001/jamanetworkopen .2022.23285.
Copyright: Institute of Sport. This is an Open Access article distributed under the terms of the Creative Commons CC BY License (https://creativecommons.org/licenses/by/4.0/). This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
  
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