eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2019
vol. 44
 
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abstract:
Clinical immunology

Biological and genetic evaluation of IL-23/IL-17 pathway in ankylosing spondylitis patients

Hulya Deveci
,
Ayla Caglıyan Turk
,
Zeliha Cansel Ozmen
,
Ayse Kevser Demir
,
Safiye Umut Say Coskun

(Centr Eur Immunol 2019; 44 (4): 433-439)
Online publish date: 2020/01/20
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Ankylosing spondylitis is the most common form of the chronic inflammatory disease group known as spondyloarthritides. Recent discoveries of the CD4+ Th17 cells and IL-23/IL-17 axis have changed the paradigms in many autoimmune diseases. In this study, we aimed to evaluate the importance of IL-23/IL-17 pathway and IL-23 receptor polymorphism in the pathogenesis of ankylosing spondylitis. Blood samples for this study were obtained from 109 ankylosing spondylitis patients and 40 healthy control subjects. Serum levels of TNF-, IL-6, IL-17, and IL-23 were measured by the ELISA method. The IL-23R gene polymorphisms rs11209026 (Arg381Gln) and rs4131362 (Val362Ile) were performed by the Sanger Sequence method. IL-6 levels were higher in the active and inactive ankylosing spondylitis groups than in the control group. However, levels of IL-17 and IL-23 were lower in the patient group. The frequency of IL-23R gene rs11209026 and rs4131362 polymorphism were 3.7% and 8.3% in the patient, respectively. As a result, dysregulation of the IL-23 / IL-17 pathway, which is caused by reduced levels of IL-17 and IL-23 in systemic circulation in patients with ankylosing spondylitis, may contribute to the pathogenesis of the disease by systemically producing chronic autoimmune inflammation.
keywords:

polymorphism, ankylosing spondylitis, cytokine, IL-17, IL-23, signalling pathways

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