eISSN: 2084-9834
ISSN: 0034-6233
Reumatologia/Rheumatology
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4/2010
vol. 48
 
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abstract:
Review paper

Bone marrow – physiological functions and its contribution to the pathogenesis of rheumatoid arthritis

Weronika Kurowska
,
Ewa Kuca-Warnawin
,
Włodzimierz Maśliński

Reumatologia 2010; 48, 4: 247-256
Online publish date: 2010/09/21
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It was recently shown that bone marrow functions not only as a primary lymphoid organ responsible for hematopoiesis, but also as a secondary lymphoid organ, where inflammatory response can be initiated. In addition, accumulating reports have indicated that bone marrow participates in the development of rheumatoid arthritis as a site of activated lymphocytes homing and proinflammatory cytokines overproduction. In the present paper, the role of bone marrow in normal (physiological) immune response is briefly described. Moreover, the results of experimental and clinical investigations that confirm the contribution of bone marrow to the pathogenesis of rheumatoid arthritis are reviewed.
keywords:

bone marrow, rheumatoid arthritis, immunopathogenesis







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