Can serum histone H4 levels predict mucosal healing in Crohn’s disease?

Ibrahim Hakki Köker; Bilge Sumbul Gultepe; Sercan Kiremitçi; Koray Koçhan; Ali Tuzun Ince; Elmas Biberci Keskin; Hakan Senturk

doi:10.5114/pg.2021.106663

Abstract

2/2021 vol. 16

Original paper

Can serum histone H4 levels predict mucosal healing in Crohn’s disease?

Ibrahim Hakki Köker ¹

,

Bilge Sumbul Gultepe ¹

,

Sercan Kiremitçi ¹

,

Koray Koçhan ¹

,

Ali Tuzun Ince ¹

,

Elmas Biberci Keskin ¹

,

Hakan Senturk ¹

Department of Gastroenterology, Medicine Faculty, Bezmialem Vakif University, Fatih, Istanbul, Turkey

Gastroenterology Rev 2021; 16 (2): 127–131

DOI: https://doi.org/10.5114/pg.2021.106663

Online publish date: 2021/06/04

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AMA

Hakki Köker I, Sumbul Gultepe B, Kiremitçi S, et al. Can serum histone H4 levels predict mucosal healing in Crohn’s disease?. Gastroenterology Review/Przegląd Gastroenterologiczny. 2021;16(2):127-131. doi:10.5114/pg.2021.106663.

APA

Hakki Köker, I., Sumbul Gultepe, B., Kiremitçi, S., Koçhan, K., Tuzun Ince, A., & Biberci Keskin, E. et al. (2021). Can serum histone H4 levels predict mucosal healing in Crohn’s disease?. Gastroenterology Review/Przegląd Gastroenterologiczny, 16(2), 127-131. https://doi.org/10.5114/pg.2021.106663

Chicago

Hakki Köker, Ibrahim, Bilge Sumbul Gultepe, Sercan Kiremitçi, Koray Koçhan, Ali Tuzun Ince, Elmas Biberci Keskin, and Hakan Senturk. 2021. "Can serum histone H4 levels predict mucosal healing in Crohn’s disease?". Gastroenterology Review/Przegląd Gastroenterologiczny 16 (2): 127-131. doi:10.5114/pg.2021.106663.

Harvard

Hakki Köker, I., Sumbul Gultepe, B., Kiremitçi, S., Koçhan, K., Tuzun Ince, A., Biberci Keskin, E., and Senturk, H. (2021). Can serum histone H4 levels predict mucosal healing in Crohn’s disease?. Gastroenterology Review/Przegląd Gastroenterologiczny, 16(2), pp.127-131. https://doi.org/10.5114/pg.2021.106663

MLA

Hakki Köker, Ibrahim et al. "Can serum histone H4 levels predict mucosal healing in Crohn’s disease?." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 16, no. 2, 2021, pp. 127-131. doi:10.5114/pg.2021.106663.

Vancouver

Hakki Köker I, Sumbul Gultepe B, Kiremitçi S, Koçhan K, Tuzun Ince A, Biberci Keskin E et al. Can serum histone H4 levels predict mucosal healing in Crohn’s disease?. Gastroenterology Review/Przegląd Gastroenterologiczny. 2021;16(2):127-131. doi:10.5114/pg.2021.106663.

Introduction

Mucosal healing (MH) has been a treatment target with the introduction of biological agents in Crohn’s disease (CD). Histone H4 increases in chronic inflammation. Aim: Our goal was to investigate the role of serum histone H4 in predicting MH.

Material and methods

The study included 44 patients who applied to the endoscopy unit for ileocolonoscopic evaluation with the diagnosis of ileocecal CD and 26 healthy controls. After ileocolonoscopic evaluation, we divided the patients into 2 groups: those with and those without MH, according to the presence of endoscopic ulcer or erosion findings. Blood samples were taken from these patients to analyse serum histone H4 before the endoscopic procedure. We first compared serum histone H4 levels between CD patients and the healthy control group and then between those with and those without MH among the CD patients. Finally, we compared CRP, ESR, and serum histone H4 levels in patients with CD according to the presence of MH and symptoms.

Results

Serum histone H4 levels were significantly higher in ileocolonic CD patients compared to the healthy control group (p = 0.002). Also, serum histone H4 levels were significantly higher in CD patients with no MH (p = 0.028) or symptomatic patients (p = 0.033). We did not find a significant difference in C-reactive protein and erythrocyte sedimentation rate levels between CD patients in the presence of MH (p = 0.281 and p = 0.203, respectively) or symptoms (0.779 and 0.652, respectively).