eISSN: 2081-2841
ISSN: 1689-832X
Journal of Contemporary Brachytherapy
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1/2019
vol. 11
 
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abstract:
Original paper

Changes in magnetic resonance imaging T2-weighted imaging signal intensity correlated with concurrent chemoradiotherapy response in cervical cancer

Bing Liu, Wan-Ling Ma, Guang-Wen Zhang, Zhen Sun, Jin-Man Zhong, Meng-Qi Wei, Hua Yang, Li-Chun Wei, Yi Huan

J Contemp Brachytherapy 2019; 11, 1: 41–47
Online publish date: 2019/02/28
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Purpose
This study is aimed to compare magnetic resonance imaging (MRI) parameters and clinical pathological factors (CPF) of residual tumor group with non-residual tumor group in cervical cancer (CC) patients during concurrent chemoradiotherapy (CCRT), and thus to establish a biomarker for individualized treatment strategy.

Material and methods
From May 2014 to November 2015, 164 CC patients were included in this retrospective study. T2-weighted MRI was performed at pre-treatment (week-0), the completion of external radiotherapy (RT) (week-4), and one month after the completion of CCRT, using 3.0T MR scanner with regular pelvic coil. Mean signal intensity and tumor size on T2WI images were measured and calculated for each tumor, and lumbar 4-5 intervertebral disc at week-0 and week-4. All patients subsequently underwent routine follow-up, including periodic clinical and imaging examinations when necessary. Receiver operator characteristics (ROC) analysis were conducted to determine cut-off values.

Results
The residual tumor group showed a higher Δ tumor-to-disc signal intensity ratio (ΔTDR) than non-residual tumor group (0.78 ± 0.30 vs. 0.48 ± 0.19, t = 3.42, p < 0.05). The biomarker of combined MRI parameter and CPF showed the highest diagnostic performance than single MRI parameter or CPF alone.

Conclusions
MRI parameter ΔTDR may be an independent prognostic factor for predicting residual tumor occurrence in CC after CCRT treatment. The combination of MRI parameter and CPF can serve as a valuable biomarker to distinguish CC with higher possibility of residual tumor occurrence.

keywords:

cervical cancer, magnetic resonance imaging, signal intensity, concurrent chemoradiotherapy, treatment response

references:
Di J, Rutherford S, Chu C. Review of the cervical cancer burden and population-based cervical cancer screening in China. Asian Pac J Cancer Prev 2015; 16: 7401-7407.
Narayan K, Lin MY. Staging for cervix cancer: Role of radiology, surgery and clinical assessment. Best Pract Res Clin Obstet Gynaecol 2015; 29: 833-844.
Fu ZZ, Li K, Peng Y et al. Efficacy and toxicity of different concurrent chemoradiotherapy regimens in the treatment of advanced cervical cancer: A network meta-analysis. Medicine (Baltimore) 2017; 96: e5853.
Dasari S, Wudayagiri R, Valluru L. Cervical cancer: Biomarkers for diagnosis and treatment. Clin Chim Acta 2015; 445: 7-11.
Gourtsoyianni S, Goh V. MRI of anal cancer: assessing response to definitive chemoradiotherapy. Abdom Imaging 2014; 39: 2-17.
Flueckiger F, Ebner F, Poschauko H et al. Cervical cancer: serial MR imaging before and after primary radiation therapy – a 2-year follow-up study. Radiology 1992; 184: 89-93.
Lim KK, Noe G, Hornsey E et al. Clinical applications of 3D T2-weighted MRI in pelvic imaging. Abdom Imaging 2014; 39: 1052-1062.
Luparia A, Mariscotti G, Durando M et al. Accuracy of tumour size assessment in the preoperative staging of breast cancer: comparison of digital mammography, tomosynthesis, ultrasound and MRI. Radiol Med 2013; 118: 1119-1136.
Toita T. Concurrent chemoradiotherapy (CCRT) in uterine cervical cancer. Nihon Rinsho 2012; 70 (Suppl 4): 255-259.
Kuang F, Yan Z, Wang J et al. The value of diffusion-weighted MRI to evaluate the response to radiochemotherapy for cervical cancer. Magn Reson Imaging 2014; 32: 342-349.
Yang W, Qiang JW, Tian HP et al. Multi-parametric MRI in cervical cancer: early prediction of response to concurrent chemoradiotherapy in combination with clinical prognostic factors. Eur Radiol 2018; 28: 437-445.
Kim S, Han K, Seo N et al. T2-weighted signal intensity-selected volumetry for prediction of pathological complete response after preoperative chemoradiotherapy in locally advanced rectal cancer. Eur Radiol 2018; 28: 5231-5240.
King AD, Keung CK, Yu KH et al. T2-weighted MR imaging early after chemoradiotherapy to evaluate treatment response in head and neck squamous cell carcinoma. AJNR Am J Neuroradiol 2013; 34: 1237-1241.
Moding EJ, Kastan MB, Kirsch DG. Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov 2013; 12: 526-542.
Hannawa AF, Roter DL. TRACEing the roots: a diagnostic “Tool for Retrospective Analysis of Critical Events”. Patient Educ Couns 2013; 93: 230-238.
 
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