eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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3/2014
vol. 39
 
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abstract:

Clinical immunology
Cutaneous expressions of interleukin-6 and neutrophil elastase as well as levels of serum IgA antibodies to gliadin nonapeptides, tissue transglutaminase and epidermal transglutaminase: implications for both autoimmunity and autoinflammation involvement in dermatitis herpetiformis

Justyna Gornowicz-Porowska, Monika Bowszyc-Dmochowska, Agnieszka Seraszek-Jaros, Elżbieta Kaczmarek, Paweł Pietkiewicz, Marian Dmochowski

(Centr Eur J Immunol 2014; 39 (3): 331-337)
Online publish date: 2014/10/14
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Introduction: Dermatitis herpetiformis (DH) seems to be a chronic immune-mediated inflammatory disease of partially known origin. In light of its known biological functions and its involvement in tissue pathology in other disease states, particularly in nickel-induced allergic contact dermatitis coexisting with DH, it would appear that the central and peripheral response by neutrophils and their mediators (e.g. neutrophil elastase – NE) in DH may be partially mediated by interleukin-6 (IL-6).

The aim of the study was to assess the role of IL-6 in DH lesions by examining the relationships between IL-6/NE cutaneous expression and levels of serum anti-nonapeptides of gliadin (npG) IgA, anti-tissue transglutaminase (tTG) immunoglobulin A (IgA), anti-epidermal transglutaminase (eTG) IgA in DH.

Material and methods: In total, 24 DH patients having IgA cutaneous deposition were studied. Immunohistochemistry on paraffin-embedded sections with quantitative digital morphometry was used to measure the intensity of IL-6 and NE cutaneous expressions. Levels of serum anti-npG IgA, anti-tTG IgA and anti-eTG IgA were evaluated with ELISA.

Results: We found no statistically significant correlation between the NE and IL-6 expression intensities. Our results revealed also a lack of correlations between NE/IL-6 expressions and levels of anti-npG IgA, anti-tTG IgA, anti-eTG IgA in DH. However, the IL-6 expression level was significantly lower than that of NE.

Conclusions: The lack of correlations suggested no substantial interactions between IL-6, NE, IgA/npG, IgA/tTG or IgA/eTG in DH. Presented results might indicate the heterogenetic nature of DH pathogenesis suggesting further that both autoimmune and autoinflammatory phenomena may be involved in DH cutaneous pathology.
keywords:

dermatitis herpetiformis, interleukin-6, neutrophil elastase, autoimmunity

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