eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2013
vol. 38
 
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abstract:

Clinical immunology
Effect of diet on selected parameters of antioxidative system and inflammatory processes in patients dialyzed due to diabetic kidney disease

Anna Bogacka
,
Edyta Balejko
,
Joanna Bober
,
Teresa Seidler
,
Jerzy Balejko
,
Anna Sobczak
,
Elżbieta Kucharska
,
Kazimierz Ciechanowski

(Centr Eur J Immunol 2013; 38 (2): 243-250)
Online publish date: 2013/07/08
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The aim of the study was to determine the effect of balanced diet on selected parameters of oxidative stress, immunological response and nutritional status in patients undergoing haemodialysis (HD) due to diabetic kidney disease. Forty HD patients took part in the study. The nutritional status and diets of all the patients were initially assessed and the patients were divided into two groups. The control group (C) got unchanged diet regarded by those patients as optimal. For patients in the P group, a standard diet for a patient undergoing haemodialysis treatment was introduced, considering the fundamental disease – diabetes. Albumin, total protein, leptin and interleukin 6 (IL-6) and tumor necrosis factor  (TNF-) cytokine concentrations were determined in blood plasma, and CAT and SOD enzymes activity was determined in erythrocytes by the spectrophotometric method. On the basis of the results of BMI, albumin and total protein analyses it can be stated that a well-balanced diet can limit the loss of body weight. Performed studies show that the proper diet can reduce the secretion of proinflammatory cytokines and ensure proper activity of antioxidative enzymes in the blood of HD patients.
keywords:

diabetic kidney disease, haemodialysis, nutritional state, CAT, SOD, cytokines, leptin

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