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ISSN: 1642-5758
Anaesthesiology Intensive Therapy
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vol. 54
Original paper

Comparison of mortality and serious complications in lower extremity total joint arthroplasty patients with aortic stenosis receiving spinal versus general anesthesia

Harold E. Chaves-Cardona
J. Ross Renew
Aaron C. Spaulding
Steven B. Porter

  1. Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, FL, USA
  2. Division of Health Care Delivery Research, Mayo Clinic Florida, Jacksonville, FL, USA
Anaesthesiol Intensive Ther 2022; 54, 2: 108–113
Online publish date: 2022/07/05
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Aortic stenosis (AS) is a cardiac valvular lesion that can cause sudden death. Spinal anesthesia (SA) has been considered a relative contraindication in patients with AS. We sought to compare outcomes in patients with AS undergoing SA versus general anesthesia (GA) for lower extremity total joint arthroplasty (TJA).

Material and methods
A retrospective chart review was conducted of elective, primary TJA cases between January 1, 2011, and November 30, 2017, at three tertiary care academic medical centers. Participants included 89 patients with AS undergoing TJA with SA, and 74 with AS undergoing TJA with GA. Primary endpoints included 90-day mortality, blood transfusion, hospital length of stay (LOS), and the 90-day incidence of deep vein thrombosis, pulmonary embolism, myocardial infarction, and stroke. Propensity score matching was utilized to assess differences in outcomes between patients receiving GA vs. SA.

After matching, there were no significant differences in mortality (GA 0% vs. SA 1%; OR: 1.01 [0.98, 1.05]; P = 0.498), serious complications GA 2.2% vs. SA 0%; OR: 1.00 [0.95, 1.05]; P = 0.233), blood transfusion (GA 12.4% vs. 9% SA; OR: 1.01 [0.86, 1.19]; P = 0.751) within 90 days in the GA vs. SA groups, nor hospital LOS (GA mean 3.0 vs. SA mean 2.9,  0.3 [–0.11, 0.70]; P = 0.153).

There were no differences in the incidence of mortality or serious complications in matched patients with AS undergoing elective primary lower extremity TJA under SA versus GA.


spinal anesthesia, neuraxial anesthesia, general anesthesia, aortic stenosis, total joint arthroplasty, complications

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